TY - JOUR
T1 - Transient supramolecular reconfiguration of peptide nanostructures using ultrasound
AU - Pappas, Charalampos G.
AU - Mutasa, Tapiwa
AU - Frederix, Pim W. J. M.
AU - Fleming, Scott
AU - Bia, Shuo
AU - Debnath, Sisir
AU - Kelly, Sharon M.
AU - Gachagan, Anthony
AU - Ulijn, Rein V.
PY - 2015/3/1
Y1 - 2015/3/1
N2 - Ultrasound, i.e. high frequency oscillating pressure waves, is commonly used to overcome kinetic barriers associated with dissolution, assembly and gelation.We demonstrate that ultrasound energy may also be used to achieve transient reorganization of supramolecular nanostructures, which revert back to the original state when sound is switched off. Aromatic peptide amphiphiles, Fmoc-FL and -YL were used to study the transient acoustic response. These systems showed temporary supramolecular transitions that were sequence dependent. The changes observed were due to an altered balance between H-bonding and p-stacking, giving rise in changes in chiral organisation of peptide building blocks. Transient reconfiguration was visualized by TEM and changes in supramolecular interactions characterized by fluorescence, FT-IR and CD. Remarkably, significant differences are observed when compared to thermal heating, which shows relates to the oscillating and directional characteristics of ultrasound when delivering heat to a system.
AB - Ultrasound, i.e. high frequency oscillating pressure waves, is commonly used to overcome kinetic barriers associated with dissolution, assembly and gelation.We demonstrate that ultrasound energy may also be used to achieve transient reorganization of supramolecular nanostructures, which revert back to the original state when sound is switched off. Aromatic peptide amphiphiles, Fmoc-FL and -YL were used to study the transient acoustic response. These systems showed temporary supramolecular transitions that were sequence dependent. The changes observed were due to an altered balance between H-bonding and p-stacking, giving rise in changes in chiral organisation of peptide building blocks. Transient reconfiguration was visualized by TEM and changes in supramolecular interactions characterized by fluorescence, FT-IR and CD. Remarkably, significant differences are observed when compared to thermal heating, which shows relates to the oscillating and directional characteristics of ultrasound when delivering heat to a system.
KW - ultrasound energy
KW - supramolecular reconfiguration
KW - peptide nanostructures
KW - supramolecular nanostructures
UR - http://pubs.rsc.org/en/journals/journalissues/mh
U2 - 10.1039/c4mh00223g
DO - 10.1039/c4mh00223g
M3 - Article
SN - 2051-6355
VL - 2
SP - 198
EP - 202
JO - Materials Horizons
JF - Materials Horizons
IS - 2
ER -