Transamination chemistry of sodium TMP-zincate: synthesis and crystal structure of a chiral amidozincate

D.R. Armstrong; W. Clegg; S.H. Dale; Joaquin Garcia-Alvarez; R.W. Harrington; E. Hevia; G.W. Honeyman; A.R. Kennedy; R.E. Mulvey; C.T. O'Hara

doi:10.1039/b713987j

Transamination chemistry of sodium TMP-zincate: synthesis and crystal structure of a chiral amidozincate

D.R. Armstrong, W. Clegg, S.H. Dale, Joaquin Garcia-Alvarez, R.W. Harrington, E. Hevia, G.W. Honeyman, A.R. Kennedy, R.E. Mulvey, C.T. O'Hara

Pure And Applied Chemistry

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

In a new type of reactivity for sodium TMP-zincate [(TMEDA) NaZn(Bu-t)(2)(TMP)] (1), transamination reactions with the amines diisopropylamine, DA(H), hexamethyldisilazane, HMDS(H) and chiral (R)-N-benzyl-alpha-methylbenzylamine have produced new sodium amido-di-tert-butyl zincates (all structurally characterised) with concomitant loss of TMP(H).

Original language	English
Pages (from-to)	187-189
Number of pages	2
Journal	Chemical Communications (London)
Issue number	2
DOIs	https://doi.org/10.1039/b713987j
Publication status	Published - 2008

Keywords

metal mediated zincation
directed ortho metalation
magnesium
amides
base
reactivity
complexes
alkoxides
alkyl

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10.1039/b713987j

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@article{78200278d6964246aadfeb8fbb1be45f,

title = "Transamination chemistry of sodium TMP-zincate: synthesis and crystal structure of a chiral amidozincate",

abstract = "In a new type of reactivity for sodium TMP-zincate [(TMEDA) NaZn(Bu-t)(2)(TMP)] (1), transamination reactions with the amines diisopropylamine, DA(H), hexamethyldisilazane, HMDS(H) and chiral (R)-N-benzyl-alpha-methylbenzylamine have produced new sodium amido-di-tert-butyl zincates (all structurally characterised) with concomitant loss of TMP(H).",

keywords = "metal mediated zincation, directed ortho metalation, magnesium, amides, base, reactivity, complexes, alkoxides, alkyl",

author = "D.R. Armstrong and W. Clegg and S.H. Dale and Joaquin Garcia-Alvarez and R.W. Harrington and E. Hevia and G.W. Honeyman and A.R. Kennedy and R.E. Mulvey and C.T. O'Hara",

note = "Strathprints' policy is to record up to 8 authors per publication, plus any additional authors based at the University of Strathclyde. More authors may be listed on the official publication than appear in the Strathprints' record.",

year = "2008",

doi = "10.1039/b713987j",

language = "English",

pages = "187--189",

journal = "Chemical Communications (London)",

issn = "0009-241X",

publisher = "Chemical Society",

number = "2",

}

TY - JOUR

T1 - Transamination chemistry of sodium TMP-zincate: synthesis and crystal structure of a chiral amidozincate

AU - Armstrong, D.R.

AU - Clegg, W.

AU - Dale, S.H.

AU - Garcia-Alvarez, Joaquin

AU - Harrington, R.W.

AU - Hevia, E.

AU - Honeyman, G.W.

AU - Kennedy, A.R.

AU - Mulvey, R.E.

AU - O'Hara, C.T.

N1 - Strathprints' policy is to record up to 8 authors per publication, plus any additional authors based at the University of Strathclyde. More authors may be listed on the official publication than appear in the Strathprints' record.

PY - 2008

Y1 - 2008

N2 - In a new type of reactivity for sodium TMP-zincate [(TMEDA) NaZn(Bu-t)(2)(TMP)] (1), transamination reactions with the amines diisopropylamine, DA(H), hexamethyldisilazane, HMDS(H) and chiral (R)-N-benzyl-alpha-methylbenzylamine have produced new sodium amido-di-tert-butyl zincates (all structurally characterised) with concomitant loss of TMP(H).

AB - In a new type of reactivity for sodium TMP-zincate [(TMEDA) NaZn(Bu-t)(2)(TMP)] (1), transamination reactions with the amines diisopropylamine, DA(H), hexamethyldisilazane, HMDS(H) and chiral (R)-N-benzyl-alpha-methylbenzylamine have produced new sodium amido-di-tert-butyl zincates (all structurally characterised) with concomitant loss of TMP(H).

KW - metal mediated zincation

KW - directed ortho metalation

KW - magnesium

KW - amides

KW - base

KW - reactivity

KW - complexes

KW - alkoxides

KW - alkyl

UR - http://dx.doi.org/10.1039/b713987j

U2 - 10.1039/b713987j

DO - 10.1039/b713987j

M3 - Article

SN - 0009-241X

SP - 187

EP - 189

JO - Chemical Communications (London)

JF - Chemical Communications (London)

IS - 2

ER -

Transamination chemistry of sodium TMP-zincate: synthesis and crystal structure of a chiral amidozincate

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Keywords

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Mixed-Metal Molecular Synergy and its Application in Inverse Crown Chemistry

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Transamination chemistry of sodium TMP-zincate: synthesis and crystal structure of a chiral amidozincate

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Mixed-Metal Molecular Synergy and its Application in Inverse Crown Chemistry

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x-ray diffractometer

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