Toxoplasma infection and response to novelty in mice

J. Hay, P.P. Aitken, D.I. Graham

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Three groups of mice were infected with Toxoplasma and used for behavioral testing using a Y-maze. One group was infected when adult and two groups congenitally, one of these born to dams infected during gestation, the other to dams chronically infected prior to mating. In an initial habituation period each mouse was exposed to a black arm and stem of the maze, entrance to a white arm being blocked by a transparent door. In a subsequent free-choice trial both arms were black and the mouse was free to explore all parts of the maze. During both periods infected mice were more active than controls. Infected mice engaged in less grooming behaviour indicative of less approach-avoidance conflict than controls prior to entry into a choice arm at the beginning of the free-choice trial. It is suggested that the reported behavioural changes would lead to dissemination of the infection in the environment by ultimately making infected mouse intermediate hosts more susceptible to predation by domestic cats, the definitive hosts of Toxoplasma.
LanguageEnglish
Pages575-588
Number of pages13
JournalParasitology Research (Zeitschrift fur Parasitenkunde)
Volume70
Issue number5
DOIs
Publication statusPublished - 1984

Fingerprint

Toxoplasma
Infection
Grooming
Cats
Pregnancy

Keywords

  • toxoplasma
  • mice
  • animal behaviour
  • animal behavior

Cite this

Hay, J. ; Aitken, P.P. ; Graham, D.I. / Toxoplasma infection and response to novelty in mice. In: Parasitology Research (Zeitschrift fur Parasitenkunde). 1984 ; Vol. 70, No. 5. pp. 575-588.
@article{336e84a88d724c2a9d7ac502b644fb80,
title = "Toxoplasma infection and response to novelty in mice",
abstract = "Three groups of mice were infected with Toxoplasma and used for behavioral testing using a Y-maze. One group was infected when adult and two groups congenitally, one of these born to dams infected during gestation, the other to dams chronically infected prior to mating. In an initial habituation period each mouse was exposed to a black arm and stem of the maze, entrance to a white arm being blocked by a transparent door. In a subsequent free-choice trial both arms were black and the mouse was free to explore all parts of the maze. During both periods infected mice were more active than controls. Infected mice engaged in less grooming behaviour indicative of less approach-avoidance conflict than controls prior to entry into a choice arm at the beginning of the free-choice trial. It is suggested that the reported behavioural changes would lead to dissemination of the infection in the environment by ultimately making infected mouse intermediate hosts more susceptible to predation by domestic cats, the definitive hosts of Toxoplasma.",
keywords = "toxoplasma, mice, animal behaviour, animal behavior",
author = "J. Hay and P.P. Aitken and D.I. Graham",
year = "1984",
doi = "10.1007/BF00926588",
language = "English",
volume = "70",
pages = "575--588",
journal = "Parasitology Research (Zeitschrift fur Parasitenkunde)",
issn = "0044-3255",
publisher = "Springer Verlag",
number = "5",

}

Toxoplasma infection and response to novelty in mice. / Hay, J.; Aitken, P.P.; Graham, D.I.

In: Parasitology Research (Zeitschrift fur Parasitenkunde), Vol. 70, No. 5, 1984, p. 575-588.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Toxoplasma infection and response to novelty in mice

AU - Hay, J.

AU - Aitken, P.P.

AU - Graham, D.I.

PY - 1984

Y1 - 1984

N2 - Three groups of mice were infected with Toxoplasma and used for behavioral testing using a Y-maze. One group was infected when adult and two groups congenitally, one of these born to dams infected during gestation, the other to dams chronically infected prior to mating. In an initial habituation period each mouse was exposed to a black arm and stem of the maze, entrance to a white arm being blocked by a transparent door. In a subsequent free-choice trial both arms were black and the mouse was free to explore all parts of the maze. During both periods infected mice were more active than controls. Infected mice engaged in less grooming behaviour indicative of less approach-avoidance conflict than controls prior to entry into a choice arm at the beginning of the free-choice trial. It is suggested that the reported behavioural changes would lead to dissemination of the infection in the environment by ultimately making infected mouse intermediate hosts more susceptible to predation by domestic cats, the definitive hosts of Toxoplasma.

AB - Three groups of mice were infected with Toxoplasma and used for behavioral testing using a Y-maze. One group was infected when adult and two groups congenitally, one of these born to dams infected during gestation, the other to dams chronically infected prior to mating. In an initial habituation period each mouse was exposed to a black arm and stem of the maze, entrance to a white arm being blocked by a transparent door. In a subsequent free-choice trial both arms were black and the mouse was free to explore all parts of the maze. During both periods infected mice were more active than controls. Infected mice engaged in less grooming behaviour indicative of less approach-avoidance conflict than controls prior to entry into a choice arm at the beginning of the free-choice trial. It is suggested that the reported behavioural changes would lead to dissemination of the infection in the environment by ultimately making infected mouse intermediate hosts more susceptible to predation by domestic cats, the definitive hosts of Toxoplasma.

KW - toxoplasma

KW - mice

KW - animal behaviour

KW - animal behavior

UR - http://dx.doi.org/10.1007/BF00926588

U2 - 10.1007/BF00926588

DO - 10.1007/BF00926588

M3 - Article

VL - 70

SP - 575

EP - 588

JO - Parasitology Research (Zeitschrift fur Parasitenkunde)

T2 - Parasitology Research (Zeitschrift fur Parasitenkunde)

JF - Parasitology Research (Zeitschrift fur Parasitenkunde)

SN - 0044-3255

IS - 5

ER -