Toxoplasma gondii tachyzoite-bradyzoite interconversion

Russell E Lyons, Rima McLeod, Craig W Roberts

Research output: Contribution to journalArticle

128 Citations (Scopus)

Abstract

During infection in the intermediate host, Toxoplasma gondii undergoes stage conversion between the rapidly dividing tachyzoite that is responsible for acute toxoplasmosis and the slowly replicating, encysted bradyzoite stage. This process of tachyzoite-bradyzoite interconversion is central to the pathogenesis and longevity of infection. Recent research has identified several stage-specific genes and proteins. However, despite recent advances in the understanding of Toxoplasma cell biology, more research is necessary to elucidate the complex events occurring during tachyzoite-bradyzoite interconversion. Here, a brief summary of this process is provided and a new method to characterize gene expression during interconversion is introduced.

LanguageEnglish
Pages198-201
Number of pages4
JournalTrends in Parasitology
Volume18
Issue number5
Early online date24 Apr 2002
DOIs
Publication statusPublished - May 2002

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Toxoplasma
Toxoplasmosis
Infection
Research
Cell Biology
Gene Expression
Proteins

Keywords

  • tissue cyst formation
  • molecular-cloning
  • stage converstion
  • differential expression
  • targeted disruption
  • gene
  • antigen
  • surface
  • induction
  • enzymes

Cite this

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abstract = "During infection in the intermediate host, Toxoplasma gondii undergoes stage conversion between the rapidly dividing tachyzoite that is responsible for acute toxoplasmosis and the slowly replicating, encysted bradyzoite stage. This process of tachyzoite-bradyzoite interconversion is central to the pathogenesis and longevity of infection. Recent research has identified several stage-specific genes and proteins. However, despite recent advances in the understanding of Toxoplasma cell biology, more research is necessary to elucidate the complex events occurring during tachyzoite-bradyzoite interconversion. Here, a brief summary of this process is provided and a new method to characterize gene expression during interconversion is introduced.",
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Toxoplasma gondii tachyzoite-bradyzoite interconversion. / Lyons, Russell E; McLeod, Rima; Roberts, Craig W.

In: Trends in Parasitology, Vol. 18, No. 5, 05.2002, p. 198-201.

Research output: Contribution to journalArticle

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KW - molecular-cloning

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KW - differential expression

KW - targeted disruption

KW - gene

KW - antigen

KW - surface

KW - induction

KW - enzymes

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