Toxins 'R' Us

more pharmacological tools from nature's superstore

Research output: Contribution to journalComment/debate

24 Citations (Scopus)

Abstract

Conus venoms from marine cone snails continue to provide novel bioactive components. Two new classes of conopeptide specifically block alpha(1)-adrenoceptors (rho-conopeptide) and noradrenaline transporters (chi-conopeptides). Both classes are small peptides with two disulfide bonds. Rho-conopeptide is structurally similar to alpha-conotoxins, which block nicotinic acetylcholine receptors, whereas the chi-conopeptides are unrelated to other conotoxins. Both types of conopeptides are non-competitive blockers. Because these peptides demonstrate greater selectivity than current drugs in clinical use, they could lead to the development of improved therapeutics.
Original languageEnglish
Pages (from-to)201-203
Number of pages3
JournalTrends in Pharmacological Sciences
Volume23
Issue number5
Early online date8 May 2002
DOIs
Publication statusPublished - May 2002

Fingerprint

Conotoxins
Mollusk Venoms
Pharmacology
Norepinephrine Plasma Membrane Transport Proteins
Peptides
Snails
Nicotinic Receptors
Disulfides
Adrenergic Receptors
Cones
Pharmaceutical Preparations
Therapeutics

Keywords

  • adrenergic alpha-1 receptor antagonists
  • amino acid sequence
  • animals
  • conotoxins
  • humans
  • molecular sequence data
  • norepinephrine plasma membrane transport proteins
  • symporters

Cite this

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title = "Toxins 'R' Us: more pharmacological tools from nature's superstore",
abstract = "Conus venoms from marine cone snails continue to provide novel bioactive components. Two new classes of conopeptide specifically block alpha(1)-adrenoceptors (rho-conopeptide) and noradrenaline transporters (chi-conopeptides). Both classes are small peptides with two disulfide bonds. Rho-conopeptide is structurally similar to alpha-conotoxins, which block nicotinic acetylcholine receptors, whereas the chi-conopeptides are unrelated to other conotoxins. Both types of conopeptides are non-competitive blockers. Because these peptides demonstrate greater selectivity than current drugs in clinical use, they could lead to the development of improved therapeutics.",
keywords = "adrenergic alpha-1 receptor antagonists, amino acid sequence, animals, conotoxins, humans, molecular sequence data, norepinephrine plasma membrane transport proteins, symporters",
author = "Harvey, {Alan L}",
year = "2002",
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doi = "10.1016/S0165-6147(02)02012-6",
language = "English",
volume = "23",
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journal = "Trends in Pharmacological Sciences",
issn = "0165-6147",
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}

Toxins 'R' Us : more pharmacological tools from nature's superstore. / Harvey, Alan L.

In: Trends in Pharmacological Sciences, Vol. 23, No. 5, 05.2002, p. 201-203.

Research output: Contribution to journalComment/debate

TY - JOUR

T1 - Toxins 'R' Us

T2 - more pharmacological tools from nature's superstore

AU - Harvey, Alan L

PY - 2002/5

Y1 - 2002/5

N2 - Conus venoms from marine cone snails continue to provide novel bioactive components. Two new classes of conopeptide specifically block alpha(1)-adrenoceptors (rho-conopeptide) and noradrenaline transporters (chi-conopeptides). Both classes are small peptides with two disulfide bonds. Rho-conopeptide is structurally similar to alpha-conotoxins, which block nicotinic acetylcholine receptors, whereas the chi-conopeptides are unrelated to other conotoxins. Both types of conopeptides are non-competitive blockers. Because these peptides demonstrate greater selectivity than current drugs in clinical use, they could lead to the development of improved therapeutics.

AB - Conus venoms from marine cone snails continue to provide novel bioactive components. Two new classes of conopeptide specifically block alpha(1)-adrenoceptors (rho-conopeptide) and noradrenaline transporters (chi-conopeptides). Both classes are small peptides with two disulfide bonds. Rho-conopeptide is structurally similar to alpha-conotoxins, which block nicotinic acetylcholine receptors, whereas the chi-conopeptides are unrelated to other conotoxins. Both types of conopeptides are non-competitive blockers. Because these peptides demonstrate greater selectivity than current drugs in clinical use, they could lead to the development of improved therapeutics.

KW - adrenergic alpha-1 receptor antagonists

KW - amino acid sequence

KW - animals

KW - conotoxins

KW - humans

KW - molecular sequence data

KW - norepinephrine plasma membrane transport proteins

KW - symporters

U2 - 10.1016/S0165-6147(02)02012-6

DO - 10.1016/S0165-6147(02)02012-6

M3 - Comment/debate

VL - 23

SP - 201

EP - 203

JO - Trends in Pharmacological Sciences

JF - Trends in Pharmacological Sciences

SN - 0165-6147

IS - 5

ER -