Toxins from mamba venoms: small proteins with selectivities for different subtypes of muscarinic acetylcholine receptors

D Jerusalinsky, A L Harvey

Research output: Contribution to journalLiterature review

77 Citations (Scopus)

Abstract

Muscarinic acetylcholine receptors exist as five subtypes that are widely distributed throughout the body. Conventional pharmacological agents are not highly selective for particular subtypes, making investigations on the functional significance of the subtypes difficult. Recent findings indicate that mamba snake venoms contain several small proteins ('muscarinic toxins') that are highly specific for muscarinic receptors, and are discussed in this review by Diana Jerusalinsky and Alan Harvey. Some of these toxins act selectively and irreversibly on individual subtypes of receptor, and some are antagonists, while others activate muscarinic receptors. The toxins should be useful tools in studies of the functions of individual receptor subtypes, and comparisons of their three-dimensional structures should give clues about how selective binding to muscarinic receptor subtypes can be obtained.
LanguageEnglish
Pages424-430
Number of pages7
JournalTrends in Pharmacological Sciences
Volume15
Issue number11
DOIs
Publication statusPublished - Nov 1994

Fingerprint

Elapidae
Venoms
Muscarinic Receptors
Proteins
Snake Venoms
Cholinergic Agents
Pharmacology

Keywords

  • amino acid sequence
  • animals
  • elapid venoms
  • molecular sequence data
  • proteins
  • muscarinic receptors
  • biological toxins

Cite this

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abstract = "Muscarinic acetylcholine receptors exist as five subtypes that are widely distributed throughout the body. Conventional pharmacological agents are not highly selective for particular subtypes, making investigations on the functional significance of the subtypes difficult. Recent findings indicate that mamba snake venoms contain several small proteins ('muscarinic toxins') that are highly specific for muscarinic receptors, and are discussed in this review by Diana Jerusalinsky and Alan Harvey. Some of these toxins act selectively and irreversibly on individual subtypes of receptor, and some are antagonists, while others activate muscarinic receptors. The toxins should be useful tools in studies of the functions of individual receptor subtypes, and comparisons of their three-dimensional structures should give clues about how selective binding to muscarinic receptor subtypes can be obtained.",
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Toxins from mamba venoms : small proteins with selectivities for different subtypes of muscarinic acetylcholine receptors. / Jerusalinsky, D; Harvey, A L.

In: Trends in Pharmacological Sciences, Vol. 15, No. 11, 11.1994, p. 424-430.

Research output: Contribution to journalLiterature review

TY - JOUR

T1 - Toxins from mamba venoms

T2 - Trends in Pharmacological Sciences

AU - Jerusalinsky, D

AU - Harvey, A L

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AB - Muscarinic acetylcholine receptors exist as five subtypes that are widely distributed throughout the body. Conventional pharmacological agents are not highly selective for particular subtypes, making investigations on the functional significance of the subtypes difficult. Recent findings indicate that mamba snake venoms contain several small proteins ('muscarinic toxins') that are highly specific for muscarinic receptors, and are discussed in this review by Diana Jerusalinsky and Alan Harvey. Some of these toxins act selectively and irreversibly on individual subtypes of receptor, and some are antagonists, while others activate muscarinic receptors. The toxins should be useful tools in studies of the functions of individual receptor subtypes, and comparisons of their three-dimensional structures should give clues about how selective binding to muscarinic receptor subtypes can be obtained.

KW - amino acid sequence

KW - animals

KW - elapid venoms

KW - molecular sequence data

KW - proteins

KW - muscarinic receptors

KW - biological toxins

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DO - 10.1016/0165-6147(94)90092-2

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