Toxins affecting k+ channels

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Abstract

Potassium channels are involved in modulating the excitability of neurones by regulating the membrane potential, or by affecting the amount of neurotransmitter released from nerve terminals. Potassium channels are highly diverse and can be activated by either voltage or increased intracellular calcium concentration. The potassium channel forms a highly selective membrane pore. Four subunits each with six membrane-spanning regions (S1-S6) are required to produce a functional pore. Molecular biologists have cloned more than 50 different potassium channel subtypes. Naturally occurring protein toxins have been used to pharmacologically characterize native and cloned potassium channels.
Original languageEnglish
Pages (from-to)1765-1780
Number of pages15
JournalBrazilian Journal of Medical and Biological Research
Volume29
Issue number12
Publication statusPublished - Dec 1996
EventII Workshop in Comparative Animal Physiology - SERRA NEGRA, Brazil
Duration: 21 Aug 199523 Aug 1995

Keywords

  • voltage-dependent potassium channels
  • calcium-dependent potassium channels
  • potassium channel toxins
  • neuropharmacology
  • molecular pharmacology

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