Towards the total synthesis of Agariblazeispirol C

Laura C Paterson, William J Kerr, Andrew Sutherland

Research output: Contribution to journalMeeting abstract

Abstract

Efforts within our laboratory have focused towards the synthesis of Agariblazeispirol C, 1, which was recently isolated from the cultured mycelia of Agaricus blazei. Our proposed pathway for gaining access to Agariblazeispirol C centres on the strategic employment of metal-mediated cyclisation chemistry. Specifically, an intramolecular Pauson-Khand reaction (PKR) will be used to construct the C/D ring section of the natural target, and a novel intramolecular Heck reaction will establish the key all carbon quaternary centre between rings B and C.
LanguageEnglish
PagesORGN-118
JournalAbstracts of papers - American Chemical Society
Volume240
Publication statusPublished - 22 Aug 2010

Fingerprint

Cyclization
Carbon
Metals
rings
synthesis
chemistry
carbon
metals

Keywords

  • Agaricus blazei
  • Agariblazeispirol C
  • Pauson-Khand reaction (PKR)

Cite this

Paterson, Laura C ; Kerr, William J ; Sutherland, Andrew. / Towards the total synthesis of Agariblazeispirol C. In: Abstracts of papers - American Chemical Society. 2010 ; Vol. 240. pp. ORGN-118.
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Towards the total synthesis of Agariblazeispirol C. / Paterson, Laura C; Kerr, William J; Sutherland, Andrew.

In: Abstracts of papers - American Chemical Society, Vol. 240, 22.08.2010, p. ORGN-118.

Research output: Contribution to journalMeeting abstract

TY - JOUR

T1 - Towards the total synthesis of Agariblazeispirol C

AU - Paterson, Laura C

AU - Kerr, William J

AU - Sutherland, Andrew

PY - 2010/8/22

Y1 - 2010/8/22

N2 - Efforts within our laboratory have focused towards the synthesis of Agariblazeispirol C, 1, which was recently isolated from the cultured mycelia of Agaricus blazei. Our proposed pathway for gaining access to Agariblazeispirol C centres on the strategic employment of metal-mediated cyclisation chemistry. Specifically, an intramolecular Pauson-Khand reaction (PKR) will be used to construct the C/D ring section of the natural target, and a novel intramolecular Heck reaction will establish the key all carbon quaternary centre between rings B and C.

AB - Efforts within our laboratory have focused towards the synthesis of Agariblazeispirol C, 1, which was recently isolated from the cultured mycelia of Agaricus blazei. Our proposed pathway for gaining access to Agariblazeispirol C centres on the strategic employment of metal-mediated cyclisation chemistry. Specifically, an intramolecular Pauson-Khand reaction (PKR) will be used to construct the C/D ring section of the natural target, and a novel intramolecular Heck reaction will establish the key all carbon quaternary centre between rings B and C.

KW - Agaricus blazei

KW - Agariblazeispirol C

KW - Pauson-Khand reaction (PKR)

M3 - Meeting abstract

VL - 240

SP - ORGN-118

JO - Abstracts of papers - American Chemical Society

T2 - Abstracts of papers - American Chemical Society

JF - Abstracts of papers - American Chemical Society

SN - 0065-7727

ER -