Towards the total synthesis of agariblazeispirol C

William Kerr, Laura Paterson, Andrew J. Sutherland

Research output: Contribution to conferenceSpeech


Efforts within our laboratory have focused towards the synthesis of Agariblazeispirol C, 1, which was recently isolated from the cultured mycelia of Agaricus blazei. Our proposed pathway for gaining access to Agariblazeispirol C centres on the strategic employment of metal-mediated cyclisation chemistry. Specifically, an intramolecular Pauson-Khand reaction (PKR) will be used to construct the C/D ring section of the natural target, and a novel intramolecular Heck reaction will establish the key all carbon quaternary centre between rings B and C.
Original languageEnglish
Publication statusPublished - 22 Aug 2010
Event240th ACS National Meeting & Exposition - Boston Convention & Exhibition Center, Boston, Massachusetts, United States
Duration: 22 Aug 201026 Aug 2010


Conference240th ACS National Meeting & Exposition
Country/TerritoryUnited States
CityBoston, Massachusetts


  • total synthesis
  • agariblazeispirol C
  • Agaricus blazei
  • metal-mediated cyclisation
  • Pauson-Khand reaction
  • Heck reaction


Dive into the research topics of 'Towards the total synthesis of agariblazeispirol C'. Together they form a unique fingerprint.

Cite this