Abstract
Efforts within our laboratory have focused towards the synthesis of Agariblazeispirol C, 1, which was recently isolated from the cultured mycelia of Agaricus blazei. Our proposed pathway for gaining access to Agariblazeispirol C centres on the strategic employment of metal-mediated cyclisation chemistry. Specifically, an intramolecular Pauson-Khand reaction (PKR) will be used to construct the C/D ring section of the natural target, and a novel intramolecular Heck reaction will establish the key all carbon quaternary centre between rings B and C.
| Original language | English |
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| Publication status | Published - 22 Aug 2010 |
| Event | 240th ACS National Meeting & Exposition - Boston Convention & Exhibition Center, Boston, Massachusetts, United States Duration: 22 Aug 2010 → 26 Aug 2010 |
Conference
| Conference | 240th ACS National Meeting & Exposition |
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| Country/Territory | United States |
| City | Boston, Massachusetts |
| Period | 22/08/10 → 26/08/10 |
Keywords
- total synthesis
- agariblazeispirol C
- Agaricus blazei
- metal-mediated cyclisation
- Pauson-Khand reaction
- Heck reaction