Towards metal-mediated G-quartet analogues: 1,2,4-triazole nucleotides

Jamie M. Withers; Shane G. Telfer; Vyacheslav V. Filichev

doi:10.1080/15257770.2014.990156

Towards metal-mediated G-quartet analogues: 1,2,4-triazole nucleotides

Jamie M. Withers, Shane G. Telfer, Vyacheslav V. Filichev

Pure And Applied Chemistry

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

We proposed that metal-coordinating nucleotides could be used to control the assembly of G-quadruplexes through the formation of an artificial metal-centered quartet. Several guanine-rich DNA sequences containing 1,2,4-triazole-functionalized nucleotides were investigated. These oligonucleotides were designed to form quartets mediated by metal-triazole bonding both on the surface of and within the G-quadruplex core. In contrast to duplex studies in which 1,2,4-triazole nucleosides serve as a mimic of Watson-Crick base-pairs, our results show that these nucleosides are not suitable components of an artificial metal-centered quartet.

Original language	English
Pages (from-to)	277-288
Number of pages	12
Journal	Nucleosides, Nucleotides & Nucleic Acids
Volume	34
Issue number	4
DOIs	https://doi.org/10.1080/15257770.2014.990156
Publication status	Published - 16 Mar 2015

Keywords

metal-coordinating nucleotides
modified oligonucleotides
G quadruplexes
DNA metal binding

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10.1080/15257770.2014.990156

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abstract = "We proposed that metal-coordinating nucleotides could be used to control the assembly of G-quadruplexes through the formation of an artificial metal-centered quartet. Several guanine-rich DNA sequences containing 1,2,4-triazole-functionalized nucleotides were investigated. These oligonucleotides were designed to form quartets mediated by metal-triazole bonding both on the surface of and within the G-quadruplex core. In contrast to duplex studies in which 1,2,4-triazole nucleosides serve as a mimic of Watson-Crick base-pairs, our results show that these nucleosides are not suitable components of an artificial metal-centered quartet.",

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AU - Withers, Jamie M.

AU - Telfer, Shane G.

AU - Filichev, Vyacheslav V.

PY - 2015/3/16

Y1 - 2015/3/16

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AB - We proposed that metal-coordinating nucleotides could be used to control the assembly of G-quadruplexes through the formation of an artificial metal-centered quartet. Several guanine-rich DNA sequences containing 1,2,4-triazole-functionalized nucleotides were investigated. These oligonucleotides were designed to form quartets mediated by metal-triazole bonding both on the surface of and within the G-quadruplex core. In contrast to duplex studies in which 1,2,4-triazole nucleosides serve as a mimic of Watson-Crick base-pairs, our results show that these nucleosides are not suitable components of an artificial metal-centered quartet.

KW - metal-coordinating nucleotides

KW - modified oligonucleotides

KW - G quadruplexes

KW - DNA metal binding

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DO - 10.1080/15257770.2014.990156

M3 - Article

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VL - 34

SP - 277

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JO - Nucleosides, Nucleotides & Nucleic Acids

JF - Nucleosides, Nucleotides & Nucleic Acids

IS - 4

ER -

Towards metal-mediated G-quartet analogues: 1,2,4-triazole nucleotides

Abstract

Keywords

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