Towards metal-mediated G-quartet analogues: 1,2,4-triazole nucleotides

Jamie M. Withers, Shane G. Telfer, Vyacheslav V. Filichev

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

We proposed that metal-coordinating nucleotides could be used to control the assembly of G-quadruplexes through the formation of an artificial metal-centered quartet. Several guanine-rich DNA sequences containing 1,2,4-triazole-functionalized nucleotides were investigated. These oligonucleotides were designed to form quartets mediated by metal-triazole bonding both on the surface of and within the G-quadruplex core. In contrast to duplex studies in which 1,2,4-triazole nucleosides serve as a mimic of Watson-Crick base-pairs, our results show that these nucleosides are not suitable components of an artificial metal-centered quartet.
Original languageEnglish
Pages (from-to)277-288
Number of pages12
JournalNucleosides, Nucleotides & Nucleic Acids
Volume34
Issue number4
DOIs
Publication statusPublished - 16 Mar 2015

Keywords

  • metal-coordinating nucleotides
  • modified oligonucleotides
  • G quadruplexes
  • DNA metal binding

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