Towards establishing a minimal nanoparticle concentration for applications involving surface enhanced spatially offset resonance Raman spectroscopy (SESORRS) in vivo

Fay Nicolson; Lauren E. Jamieson; Samuel Mabbott; Konstantinos Plakas; Neil C. Shand; Michael R. Detty; Duncan Graham; Karen Faulds

doi:10.1039/C8AN01860J

Towards establishing a minimal nanoparticle concentration for applications involving surface enhanced spatially offset resonance Raman spectroscopy (SESORRS) in vivo

Fay Nicolson, Lauren E. Jamieson, Samuel Mabbott, Konstantinos Plakas, Neil C. Shand, Michael R. Detty, Duncan Graham, Karen Faulds

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Abstract

Resonant chalcogenpyrylium nanotags demonstrate an exceptional surface enhanced Raman scattering (SERS) performance for use in SORS applications. Using surface enhanced spatially offset Raman spectroscopy (SESORS), nanotags modified with a chalcogenpyrylium dye were observed at concentrations as low as 1 pM through 5 mm of tissue. Calculated limits of detection suggest that these SERS nanotags can be detected at 104 fM using surface enhanced spatially offset resonance Raman scattering (SESORRS) demonstrating their potential for in vivo applications.

Original language	English
Pages (from-to)	5358-5363
Number of pages	6
Journal	Analyst
Volume	143
Early online date	11 Oct 2018
DOIs	https://doi.org/10.1039/C8AN01860J
Publication status	Published - 21 Nov 2018

Keywords

Raman
SERS
SORS
SESORS
SERRS
SESORRS
nanoparticle
LOD

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10.1039/C8AN01860J

Nicolson-etal-Analyst-Towards-establishing-a-minimal-nanoparticle-concentration-for-applicationsAccepted author manuscript, 706 KB

Cite this

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title = "Towards establishing a minimal nanoparticle concentration for applications involving surface enhanced spatially offset resonance Raman spectroscopy (SESORRS) in vivo",

abstract = "Resonant chalcogenpyrylium nanotags demonstrate an exceptional surface enhanced Raman scattering (SERS) performance for use in SORS applications. Using surface enhanced spatially offset Raman spectroscopy (SESORS), nanotags modified with a chalcogenpyrylium dye were observed at concentrations as low as 1 pM through 5 mm of tissue. Calculated limits of detection suggest that these SERS nanotags can be detected at 104 fM using surface enhanced spatially offset resonance Raman scattering (SESORRS) demonstrating their potential for in vivo applications.",

keywords = "Raman, SERS, SORS, SESORS, SERRS, SESORRS, nanoparticle, LOD",

author = "Fay Nicolson and Jamieson, {Lauren E.} and Samuel Mabbott and Konstantinos Plakas and Shand, {Neil C.} and Detty, {Michael R.} and Duncan Graham and Karen Faulds",

year = "2018",

month = nov,

day = "21",

doi = "10.1039/C8AN01860J",

language = "English",

volume = "143",

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journal = "Analyst",

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publisher = "Royal Society of Chemistry",

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AU - Nicolson, Fay

AU - Jamieson, Lauren E.

AU - Mabbott, Samuel

AU - Plakas, Konstantinos

AU - Shand, Neil C.

AU - Detty, Michael R.

AU - Graham, Duncan

AU - Faulds, Karen

PY - 2018/11/21

Y1 - 2018/11/21

N2 - Resonant chalcogenpyrylium nanotags demonstrate an exceptional surface enhanced Raman scattering (SERS) performance for use in SORS applications. Using surface enhanced spatially offset Raman spectroscopy (SESORS), nanotags modified with a chalcogenpyrylium dye were observed at concentrations as low as 1 pM through 5 mm of tissue. Calculated limits of detection suggest that these SERS nanotags can be detected at 104 fM using surface enhanced spatially offset resonance Raman scattering (SESORRS) demonstrating their potential for in vivo applications.

AB - Resonant chalcogenpyrylium nanotags demonstrate an exceptional surface enhanced Raman scattering (SERS) performance for use in SORS applications. Using surface enhanced spatially offset Raman spectroscopy (SESORS), nanotags modified with a chalcogenpyrylium dye were observed at concentrations as low as 1 pM through 5 mm of tissue. Calculated limits of detection suggest that these SERS nanotags can be detected at 104 fM using surface enhanced spatially offset resonance Raman scattering (SESORRS) demonstrating their potential for in vivo applications.

KW - Raman

KW - SERS

KW - SORS

KW - SESORS

KW - SERRS

KW - SESORRS

KW - nanoparticle

KW - LOD

UR - https://pubs.rsc.org/en/journals/journalissues/an#!recentarticles

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DO - 10.1039/C8AN01860J

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EP - 5363

JO - Analyst

JF - Analyst

SN - 0003-2654

ER -

Towards establishing a minimal nanoparticle concentration for applications involving surface enhanced spatially offset resonance Raman spectroscopy (SESORRS) in vivo

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Keywords

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Towards establishing a minimal nanoparticle concentration for applications involving surface enhanced spatially offset resonance Raman spectroscopy (SESORRS) in vivo

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In Situ Nanoparticle Assemblies for Healthcare Diagnostics and Therapy

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