Towards establishing a minimal nanoparticle concentration for applications involving surface enhanced spatially offset resonance Raman spectroscopy (SESORRS) in vivo

Fay Nicolson, Lauren E. Jamieson, Samuel Mabbott, Konstantinos Plakas, Neil C. Shand, Michael R. Detty, Duncan Graham, Karen Faulds

Research output: Contribution to journal › Article

1 Citation (Scopus)

Abstract

Resonant chalcogenpyrylium nanotags demonstrate an exceptional surface enhanced Raman scattering (SERS) performance for use in SORS applications. Using surface enhanced spatially offset Raman spectroscopy (SESORS), nanotags modified with a chalcogenpyrylium dye were observed at concentrations as low as 1 pM through 5 mm of tissue. Calculated limits of detection suggest that these SERS nanotags can be detected at 104 fM using surface enhanced spatially offset resonance Raman scattering (SESORRS) demonstrating their potential for in vivo applications.
LanguageEnglish
Pages5358-5363
Number of pages6
JournalAnalyst
Volume143
Early online date11 Oct 2018
DOIs
Publication statusPublished - 21 Nov 2018

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Raman Spectrum Analysis
Raman spectroscopy
Nanoparticles
Raman scattering
scattering
Limit of Detection
dye
Coloring Agents
Dyes
Tissue
nanoparticle

Keywords

  • Raman
  • SERS
  • SORS
  • SESORS
  • SERRS
  • SESORRS
  • nanoparticle
  • LOD

Cite this

Nicolson, Fay ; Jamieson, Lauren E. ; Mabbott, Samuel ; Plakas, Konstantinos ; Shand, Neil C. ; Detty, Michael R. ; Graham, Duncan ; Faulds, Karen. / Towards establishing a minimal nanoparticle concentration for applications involving surface enhanced spatially offset resonance Raman spectroscopy (SESORRS) in vivo. In: Analyst. 2018 ; Vol. 143. pp. 5358-5363.
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abstract = "Resonant chalcogenpyrylium nanotags demonstrate an exceptional surface enhanced Raman scattering (SERS) performance for use in SORS applications. Using surface enhanced spatially offset Raman spectroscopy (SESORS), nanotags modified with a chalcogenpyrylium dye were observed at concentrations as low as 1 pM through 5 mm of tissue. Calculated limits of detection suggest that these SERS nanotags can be detected at 104 fM using surface enhanced spatially offset resonance Raman scattering (SESORRS) demonstrating their potential for in vivo applications.",
keywords = "Raman, SERS, SORS, SESORS, SERRS, SESORRS, nanoparticle, LOD",
author = "Fay Nicolson and Jamieson, {Lauren E.} and Samuel Mabbott and Konstantinos Plakas and Shand, {Neil C.} and Detty, {Michael R.} and Duncan Graham and Karen Faulds",
year = "2018",
month = "11",
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doi = "10.1039/C8AN01860J",
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Nicolson, F, Jamieson, LE, Mabbott, S, Plakas, K, Shand, NC, Detty, MR, Graham, D & Faulds, K 2018, 'Towards establishing a minimal nanoparticle concentration for applications involving surface enhanced spatially offset resonance Raman spectroscopy (SESORRS) in vivo' Analyst, vol. 143, pp. 5358-5363. https://doi.org/10.1039/C8AN01860J

Towards establishing a minimal nanoparticle concentration for applications involving surface enhanced spatially offset resonance Raman spectroscopy (SESORRS) in vivo. / Nicolson, Fay; Jamieson, Lauren E.; Mabbott, Samuel; Plakas, Konstantinos; Shand, Neil C.; Detty, Michael R.; Graham, Duncan; Faulds, Karen.

In: Analyst, Vol. 143, 21.11.2018, p. 5358-5363.

Research output: Contribution to journal › Article

TY - JOUR

T1 - Towards establishing a minimal nanoparticle concentration for applications involving surface enhanced spatially offset resonance Raman spectroscopy (SESORRS) in vivo

AU - Nicolson, Fay

AU - Jamieson, Lauren E.

AU - Mabbott, Samuel

AU - Plakas, Konstantinos

AU - Shand, Neil C.

AU - Detty, Michael R.

AU - Graham, Duncan

AU - Faulds, Karen

PY - 2018/11/21

Y1 - 2018/11/21

N2 - Resonant chalcogenpyrylium nanotags demonstrate an exceptional surface enhanced Raman scattering (SERS) performance for use in SORS applications. Using surface enhanced spatially offset Raman spectroscopy (SESORS), nanotags modified with a chalcogenpyrylium dye were observed at concentrations as low as 1 pM through 5 mm of tissue. Calculated limits of detection suggest that these SERS nanotags can be detected at 104 fM using surface enhanced spatially offset resonance Raman scattering (SESORRS) demonstrating their potential for in vivo applications.

AB - Resonant chalcogenpyrylium nanotags demonstrate an exceptional surface enhanced Raman scattering (SERS) performance for use in SORS applications. Using surface enhanced spatially offset Raman spectroscopy (SESORS), nanotags modified with a chalcogenpyrylium dye were observed at concentrations as low as 1 pM through 5 mm of tissue. Calculated limits of detection suggest that these SERS nanotags can be detected at 104 fM using surface enhanced spatially offset resonance Raman scattering (SESORRS) demonstrating their potential for in vivo applications.

KW - Raman

KW - SERS

KW - SORS

KW - SESORS

KW - SERRS

KW - SESORRS

KW - nanoparticle

KW - LOD

UR - https://pubs.rsc.org/en/journals/journalissues/an#!recentarticles

U2 - 10.1039/C8AN01860J

DO - 10.1039/C8AN01860J

M3 - Article

VL - 143

SP - 5358

EP - 5363

JO - Analyst

T2 - Analyst

JF - Analyst

SN - 0003-2654

ER -

Nicolson F, Jamieson LE, Mabbott S, Plakas K, Shand NC, Detty MR et al. Towards establishing a minimal nanoparticle concentration for applications involving surface enhanced spatially offset resonance Raman spectroscopy (SESORRS) in vivo. Analyst. 2018 Nov 21;143:5358-5363. https://doi.org/10.1039/C8AN01860J

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