Towards establishing a minimal nanoparticle concentration for applications involving surface enhanced spatially offset resonance Raman spectroscopy (SESORRS) in vivo

Fay Nicolson, Lauren E. Jamieson, Samuel Mabbott, Konstantinos Plakas, Neil C. Shand, Michael R. Detty, Duncan Graham, Karen Faulds

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Abstract

Resonant chalcogenpyrylium nanotags demonstrate an exceptional surface enhanced Raman scattering (SERS) performance for use in SORS applications. Using surface enhanced spatially offset Raman spectroscopy (SESORS), nanotags modified with a chalcogenpyrylium dye were observed at concentrations as low as 1 pM through 5 mm of tissue. Calculated limits of detection suggest that these SERS nanotags can be detected at 104 fM using surface enhanced spatially offset resonance Raman scattering (SESORRS) demonstrating their potential for in vivo applications.
Original languageEnglish
Pages (from-to)5358-5363
Number of pages6
JournalAnalyst
Volume143
Early online date11 Oct 2018
DOIs
Publication statusPublished - 21 Nov 2018

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Keywords

  • Raman
  • SERS
  • SORS
  • SESORS
  • SERRS
  • SESORRS
  • nanoparticle
  • LOD

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    In Situ Nanoparticle Assemblies for Healthcare Diagnostics and Therapy

    Project: Research