Abstract
Crystallization plays an important role in defining the physico-chemical characteristics of pharmaceuticals. The ubiquity of crystal nucleation reactions - as well as the strong influence on product quality - emphasises the importance of understanding and controlling the process. Within this project, we are investigating the use of liposomes to control crystallization. Due to their nano-scale size and ability to facilitate well-controlled process conditions, liposomes present an excellent vehicle for crystallization studies. It has been shown that nanocrystalline precipitates of drugs such as doxorubicin, topotecan and idarubicin can be encapsulated inside liposomes for drug delivery purposes; however, the formation of these nano-crystals has never been extensively studied. In order to control the particle size of liposomes and to establish transmembrane gradients, we have used microfluidics.
Original language | English |
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Pages | 53-53 |
Number of pages | 1 |
Publication status | Published - 16 May 2022 |
Event | CMAC Annual Open Day 2022 - Glasgow, United Kingdom Duration: 16 May 2022 → 18 May 2022 |
Conference
Conference | CMAC Annual Open Day 2022 |
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Country/Territory | United Kingdom |
City | Glasgow |
Period | 16/05/22 → 18/05/22 |
Keywords
- crystallisation
- liposomes
- microfluidics