TY - JOUR
T1 - Towards clinical translation of 'second-generation' regenerative stroke therapies
T2 - hydrogels as game changers?
AU - Totten, John D.
AU - Alhadrami, Hani Abdullah
AU - Jiffri, Essam Hussain
AU - McMullen, Calum
AU - Seib, F.Philipp
AU - Carswell, Hilary V. O.
PY - 2021/11/20
Y1 - 2021/11/20
N2 - Stroke is an unmet clinical need with a paucity of treatments, at least in part because chronic stroke pathologies are prohibitive to "first-generation" stem cell-based therapies. Hydrogels can remodel the hostile stroke microenvironment to aid endogenous and exogenous regenerative repair processes. However no clinical trials have yet been successfully commissioned for these "second-generation" hydrogel-based therapies for chronic ischemic stroke regeneration. This review recommends a path forward to improve hydrogel technology for future clinical translation for stroke. Specifically, we suggest that a better understanding of human host stroke tissue-hydrogel interactions in addition to the effects of scaling up hydrogel volume to human-sized cavities would help guide translation of these second-generation regenerative stroke therapies.
AB - Stroke is an unmet clinical need with a paucity of treatments, at least in part because chronic stroke pathologies are prohibitive to "first-generation" stem cell-based therapies. Hydrogels can remodel the hostile stroke microenvironment to aid endogenous and exogenous regenerative repair processes. However no clinical trials have yet been successfully commissioned for these "second-generation" hydrogel-based therapies for chronic ischemic stroke regeneration. This review recommends a path forward to improve hydrogel technology for future clinical translation for stroke. Specifically, we suggest that a better understanding of human host stroke tissue-hydrogel interactions in addition to the effects of scaling up hydrogel volume to human-sized cavities would help guide translation of these second-generation regenerative stroke therapies.
KW - stroke
KW - brain repair
KW - hydrogel matrix
KW - biomaterial technology
KW - scaffold
KW - tissue engineering
UR - https://www.cell.com/trends/biotechnology/home
U2 - 10.1016/j.tibtech.2021.10.009
DO - 10.1016/j.tibtech.2021.10.009
M3 - Article
SN - 0167-7799
JO - Trends in Biotechnology
JF - Trends in Biotechnology
ER -