Towards an effective, needle-based delivery device for Parkinson's disease: a simulation study on the impact of needle diameter

Research output: Contribution to conferenceAbstract

Abstract

Recently, several therapies have emerged for Parkinson’s disease, a challenging neurodegenerative disorder. However, clinical translation is restricted, partially due to limitations in delivering therapeutics to the Central Nervous System (CNS)which cannot be reached by systemic administration. An alternative method, that bypasses the blood brain barrier and offers high-concentrated deposition in the diseased region, is intrastriatal delivery of a cell-loaded in situ forming collagen hydrogel. However, this strategy has disadvantages, including neuroimmune response and haemorrhage. To minimize these responses, an optimised medical device should be designed. Of main consideration is the volume dispensed and the needle dimensions. Current approaches use 18-20-Gaugediameter needles and multiple cranial penetrations [1]. Additionally, fluid forces acting on cells may lead to cell disruption and death [2]. This study aims to develop a novel device for the effective delivery of a cell-loaded in situ forming collagen hydrogel to the CNS. A simulation study on constricted channels representing the needle was performed to gain insight into the optimal needle diameter.

Conference

Conference8th World Congress of Biomechanics
Abbreviated titleWCB
CountryIreland
CityDublin
Period8/07/1812/07/18
Internet address

Fingerprint

Needles
Neurology
Collagen
Hydrogels
Fluids

Keywords

  • Parkinson’s disease
  • optimised medical device
  • needle-based delivery

Cite this

@conference{73d10768385f438d80b5623bdb73c8a1,
title = "Towards an effective, needle-based delivery device for Parkinson's disease: a simulation study on the impact of needle diameter",
abstract = "Recently, several therapies have emerged for Parkinson’s disease, a challenging neurodegenerative disorder. However, clinical translation is restricted, partially due to limitations in delivering therapeutics to the Central Nervous System (CNS)which cannot be reached by systemic administration. An alternative method, that bypasses the blood brain barrier and offers high-concentrated deposition in the diseased region, is intrastriatal delivery of a cell-loaded in situ forming collagen hydrogel. However, this strategy has disadvantages, including neuroimmune response and haemorrhage. To minimize these responses, an optimised medical device should be designed. Of main consideration is the volume dispensed and the needle dimensions. Current approaches use 18-20-Gaugediameter needles and multiple cranial penetrations [1]. Additionally, fluid forces acting on cells may lead to cell disruption and death [2]. This study aims to develop a novel device for the effective delivery of a cell-loaded in situ forming collagen hydrogel to the CNS. A simulation study on constricted channels representing the needle was performed to gain insight into the optimal needle diameter.",
keywords = "Parkinson’s disease, optimised medical device, needle-based delivery",
author = "Syntouka, {Ioanna Marina} and Riches, {Philip E.} and Grahame Busby and Asimina Kazakidi",
year = "2018",
month = "7",
day = "8",
language = "English",
note = "8th World Congress of Biomechanics, WCB ; Conference date: 08-07-2018 Through 12-07-2018",
url = "http://wcb2018.com/",

}

Towards an effective, needle-based delivery device for Parkinson's disease : a simulation study on the impact of needle diameter. / Syntouka, Ioanna Marina; Riches, Philip E.; Busby, Grahame; Kazakidi, Asimina.

2018. Abstract from 8th World Congress of Biomechanics, Dublin, Ireland.

Research output: Contribution to conferenceAbstract

TY - CONF

T1 - Towards an effective, needle-based delivery device for Parkinson's disease

T2 - a simulation study on the impact of needle diameter

AU - Syntouka, Ioanna Marina

AU - Riches, Philip E.

AU - Busby, Grahame

AU - Kazakidi, Asimina

PY - 2018/7/8

Y1 - 2018/7/8

N2 - Recently, several therapies have emerged for Parkinson’s disease, a challenging neurodegenerative disorder. However, clinical translation is restricted, partially due to limitations in delivering therapeutics to the Central Nervous System (CNS)which cannot be reached by systemic administration. An alternative method, that bypasses the blood brain barrier and offers high-concentrated deposition in the diseased region, is intrastriatal delivery of a cell-loaded in situ forming collagen hydrogel. However, this strategy has disadvantages, including neuroimmune response and haemorrhage. To minimize these responses, an optimised medical device should be designed. Of main consideration is the volume dispensed and the needle dimensions. Current approaches use 18-20-Gaugediameter needles and multiple cranial penetrations [1]. Additionally, fluid forces acting on cells may lead to cell disruption and death [2]. This study aims to develop a novel device for the effective delivery of a cell-loaded in situ forming collagen hydrogel to the CNS. A simulation study on constricted channels representing the needle was performed to gain insight into the optimal needle diameter.

AB - Recently, several therapies have emerged for Parkinson’s disease, a challenging neurodegenerative disorder. However, clinical translation is restricted, partially due to limitations in delivering therapeutics to the Central Nervous System (CNS)which cannot be reached by systemic administration. An alternative method, that bypasses the blood brain barrier and offers high-concentrated deposition in the diseased region, is intrastriatal delivery of a cell-loaded in situ forming collagen hydrogel. However, this strategy has disadvantages, including neuroimmune response and haemorrhage. To minimize these responses, an optimised medical device should be designed. Of main consideration is the volume dispensed and the needle dimensions. Current approaches use 18-20-Gaugediameter needles and multiple cranial penetrations [1]. Additionally, fluid forces acting on cells may lead to cell disruption and death [2]. This study aims to develop a novel device for the effective delivery of a cell-loaded in situ forming collagen hydrogel to the CNS. A simulation study on constricted channels representing the needle was performed to gain insight into the optimal needle diameter.

KW - Parkinson’s disease

KW - optimised medical device

KW - needle-based delivery

UR - http://wcb2018.com/

M3 - Abstract

ER -