Towards a novel carbon device for the treatment of sepsis

S.R. Sandeman, C.A. Howell, G.J. Phillips, A.W. Lloyd, S.V. Mikhalovsky, J.G. Davies, M.C. Murphy, M. Melillo, L.M. Barnes, S.R. Tennison, O.P. Kozynchenko, J.D.S. Gaylor, J.M. Courtney

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    Abstract

    Sepsis is a systemic inflammatory response to infection in which the balance of pro- andanti-inflammatory mediators, which normally isolate and eliminate infection, is disrupted[1]. Gram negative sepsis is initiated by bacterial endotoxin release which activatesmacrophages and circulating monocytes to release TNF and IL-1β followed by IL-6 andother inflammatory cytokines [2]. As the disease progresses, an unregulatedinflammatory response results in, tissue injury, haematological dysfunction and organdysfunction. Severe sepsis, involving organ hypoperfusion may be further complicatedby hypotension that is unresponsive to adequate fluid replacement, resulting in septicshock and finally death [3].Despite improvements in anti-microbial and supportive therapies, sepsis remains asignificant cause of morbidity and mortality in ICUs worldwide [4]. The complexity ofprocesses mediating the progression of sepsis suggests that an extracorporeal devicecombining blood filtration with adsorption of a wide range of toxins, and inflammatorymediators offers the most comprehensive treatment strategy. However, no such deviceexists at present. A novel, uncoated, polymer pyrolysed synthetic carbon device isproposed which combines the superior adsorption properties of uncoated activatedcarbons with the capacity to manipulate porous structure for controlled adsorption oftarget plasma proteins and polypeptides [5]. Preliminary haemocompatibility andadsorptive capacity was assessed using a carbon matrix prototype.
    Original languageEnglish
    PagesA13-A14
    Number of pages4
    Publication statusPublished - 14 Jul 2004
    EventThe American Carbon Society - Conference held at Brown University, Providence, RI
    Duration: 11 Jul 200416 Jul 2004

    Conference

    ConferenceThe American Carbon Society
    CityConference held at Brown University, Providence, RI
    Period11/07/0416/07/04

    Keywords

    • sepsis
    • uncoated carbon well prototypes
    • carbon matrix
    • mesoporous/microporous structure
    • adsorption/filtration of pro-inflammatory cytokines
    • bacterial toxins

    Cite this

    Sandeman, S. R., Howell, C. A., Phillips, G. J., Lloyd, A. W., Mikhalovsky, S. V., Davies, J. G., Murphy, M. C., Melillo, M., Barnes, L. M., Tennison, S. R., Kozynchenko, O. P., Gaylor, J. D. S., & Courtney, J. M. (2004). Towards a novel carbon device for the treatment of sepsis. A13-A14. Paper presented at The American Carbon Society, Conference held at Brown University, Providence, RI, .