Toward single-metal-ion sensing by forster resonance energy transfer

J.U. Sutter; A.M. Macmillan; D.J.S. Birch; O.J. Rolinski

Toward single-metal-ion sensing by forster resonance energy transfer

J.U. Sutter, A.M. Macmillan, D.J.S. Birch, O.J. Rolinski

Research output: Contribution to journal › Article › peer-review

Abstract

Here we describe progress toward our objective of detecting single nonfluorescent hydrated metal ions. Single-ion detection represents detection and spectroscopy at the ultimate sensitivity level of approximately 1.6 x 10(-24) M. Achieving this goal would provide a breakthrough in analytical science and allow much more detailed insight into sensor-ion interaction than that available with conventional bulk detection methods. We combine recent advances in confocal microscopy with the sensitivity and the noninvasive nature of fluorescence by analyzing Forster resonance energy transfer between sensor fluorophores and transition metal ions.

Original language	English
Pages (from-to)	62-67
Number of pages	5
Journal	Annals of the New York Academy of Sciences
Volume	1130
Publication status	Published - 2008

Keywords

ion sensing
Forster resonance energy transfer (FRET)
quantum dots

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1 Finished

Yocto: YOCTOMOLE FLUORESCENCE SENSING OF SINGLE METAL IONS
Rolinski, O. & Birch, D.
EPSRC (Engineering and Physical Sciences Research Council)
1/10/06 → 31/08/10
Project: Research

Cite this

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title = "Toward single-metal-ion sensing by forster resonance energy transfer",

abstract = "Here we describe progress toward our objective of detecting single nonfluorescent hydrated metal ions. Single-ion detection represents detection and spectroscopy at the ultimate sensitivity level of approximately 1.6 x 10(-24) M. Achieving this goal would provide a breakthrough in analytical science and allow much more detailed insight into sensor-ion interaction than that available with conventional bulk detection methods. We combine recent advances in confocal microscopy with the sensitivity and the noninvasive nature of fluorescence by analyzing Forster resonance energy transfer between sensor fluorophores and transition metal ions.",

keywords = "ion sensing, Forster resonance energy transfer (FRET), quantum dots",

author = "J.U. Sutter and A.M. Macmillan and D.J.S. Birch and O.J. Rolinski",

note = "Document Type: Proceedings Paper",

year = "2008",

language = "English",

volume = "1130",

pages = "62--67",

journal = "Annals of the New York Academy of Sciences",

issn = "0077-8923",

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TY - JOUR

T1 - Toward single-metal-ion sensing by forster resonance energy transfer

AU - Sutter, J.U.

AU - Macmillan, A.M.

AU - Birch, D.J.S.

AU - Rolinski, O.J.

N1 - Document Type: Proceedings Paper

PY - 2008

Y1 - 2008

N2 - Here we describe progress toward our objective of detecting single nonfluorescent hydrated metal ions. Single-ion detection represents detection and spectroscopy at the ultimate sensitivity level of approximately 1.6 x 10(-24) M. Achieving this goal would provide a breakthrough in analytical science and allow much more detailed insight into sensor-ion interaction than that available with conventional bulk detection methods. We combine recent advances in confocal microscopy with the sensitivity and the noninvasive nature of fluorescence by analyzing Forster resonance energy transfer between sensor fluorophores and transition metal ions.

AB - Here we describe progress toward our objective of detecting single nonfluorescent hydrated metal ions. Single-ion detection represents detection and spectroscopy at the ultimate sensitivity level of approximately 1.6 x 10(-24) M. Achieving this goal would provide a breakthrough in analytical science and allow much more detailed insight into sensor-ion interaction than that available with conventional bulk detection methods. We combine recent advances in confocal microscopy with the sensitivity and the noninvasive nature of fluorescence by analyzing Forster resonance energy transfer between sensor fluorophores and transition metal ions.

KW - ion sensing

KW - Forster resonance energy transfer (FRET)

KW - quantum dots

M3 - Article

VL - 1130

SP - 62

EP - 67

JO - Annals of the New York Academy of Sciences

JF - Annals of the New York Academy of Sciences

SN - 0077-8923

ER -

Toward single-metal-ion sensing by forster resonance energy transfer

Abstract

Keywords

Yocto: YOCTOMOLE FLUORESCENCE SENSING OF SINGLE METAL IONS

Cite this