Toward single-metal-ion sensing by forster resonance energy transfer

J.U. Sutter, A.M. Macmillan, D.J.S. Birch, O.J. Rolinski

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


Here we describe progress toward our objective of detecting single nonfluorescent hydrated metal ions. Single-ion detection represents detection and spectroscopy at the ultimate sensitivity level of approximately 1.6 x 10(-24) M. Achieving this goal would provide a breakthrough in analytical science and allow much more detailed insight into sensor-ion interaction than that available with conventional bulk detection methods. We combine recent advances in confocal microscopy with the sensitivity and the noninvasive nature of fluorescence by analyzing Forster resonance energy transfer between sensor fluorophores and transition metal ions.
Original languageEnglish
Pages (from-to)62-67
Number of pages5
JournalAnnals of the New York Academy of Sciences
Publication statusPublished - 2008


  • ion sensing
  • Forster resonance energy transfer (FRET)
  • quantum dots


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