Through-space transfer of chiral information mediated by a plasmonic nanomaterial

Saeideh Ostovar pour, Louise Rocks, Karen Faulds, Duncan Graham, Václav Parchaňský, Petr Bouř, Ewan W. Blanch

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

The ability to detect chirality gives stereochemically attuned nanosensors the potential to revolutionise the study of biomolecular processes. Such devices may structurally characterise the mechanisms of protein-ligand binding, the intermediates of amyloidogenic diseases and the effects of phosphorylation and glycosylation. We demonstrate that single nanoparticle plasmonic reporters, or nanotags, can enable a stereochemical response to be transmitted from a chiral analyte to an achiral benzotriazole dye molecule in the vicinity of a plasmon resonance from an achiral metallic nanostructure. The transfer of chirality was verified by the measurement of mirror image surface enhanced resonance Raman optical activity spectra for the two enantiomers of each of ribose and tryptophan. Computational modelling confirms these observations and reveals the novel chirality transfer mechanism responsible. This is the first report of colloidal metal nanoparticles in the form of single plasmonic substrates displaying an intrinsic chiral sensitivity once attached to a chiral molecule.
LanguageEnglish
Pages591–596
Number of pages6
JournalNature Chemistry
Volume7
Issue number7
Early online date15 Jun 2015
DOIs
Publication statusPublished - 31 Jul 2015

Fingerprint

Chirality
Nanostructured materials
Nanosensors
Glycosylation
Phosphorylation
Molecules
Ribose
Enantiomers
Metal nanoparticles
Tryptophan
Nanostructures
Mirrors
Coloring Agents
Dyes
Ligands
Nanoparticles
Proteins
Substrates

Keywords

  • chirality
  • Raman spectra
  • chirality detection

Cite this

Ostovar pour, Saeideh ; Rocks, Louise ; Faulds, Karen ; Graham, Duncan ; Parchaňský, Václav ; Bouř, Petr ; Blanch, Ewan W. / Through-space transfer of chiral information mediated by a plasmonic nanomaterial. In: Nature Chemistry. 2015 ; Vol. 7, No. 7. pp. 591–596.
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Ostovar pour, S, Rocks, L, Faulds, K, Graham, D, Parchaňský, V, Bouř, P & Blanch, EW 2015, 'Through-space transfer of chiral information mediated by a plasmonic nanomaterial' Nature Chemistry, vol. 7, no. 7, pp. 591–596. https://doi.org/10.1038/nchem.2280

Through-space transfer of chiral information mediated by a plasmonic nanomaterial. / Ostovar pour, Saeideh; Rocks, Louise; Faulds, Karen; Graham, Duncan; Parchaňský, Václav; Bouř, Petr ; Blanch, Ewan W.

In: Nature Chemistry, Vol. 7, No. 7, 31.07.2015, p. 591–596.

Research output: Contribution to journalArticle

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