Abstract
Spatially offset Raman spectroscopy (SORS) provides chemical analysis at depth even when obscuring barriers such as plastic or tissue are present. As the collection probe is moved further away from the point of laser excitation, scattered photons from deeper layers begin to dominate the acquired spectra, thus giving rise to through barrier detection. Here, we demonstrate the potential of conventional Raman (CR) and SORS for through barrier detection using handheld spectrometers. We report the collection of Raman signals from an ethanol solution through plastic at thicknesses of up to 21 mm using SORS in combination with multivariate analysis. SORS is compared to CR, where we also demonstrate impressive through barrier detection of ethanol at depths up to 9 mm. We also highlight the advantage of applying multivariate analysis for through barrier detection using CR or SORS, particularly when peaks with similar spectral features are present in both the barrier and analyte spectra. In addition, to the best of our knowledge, this is the first report of the assessment of the maximum level of through barrier detection using handheld CR and SORS instruments with a backscattering geometry.
| Language | English |
|---|---|
| Pages | 1828-1838 |
| Number of pages | 11 |
| Journal | Journal of Raman Spectroscopy |
| Volume | 48 |
| Issue number | 12 |
| Early online date | 28 Sep 2017 |
| DOIs | |
| Publication status | Published - 20 Dec 2017 |
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Keywords
- conventional Raman
- handheld
- SORS
- through barrier detection
- spectroscopy
Cite this
}
Through barrier detection of ethanol using handheld Raman spectroscopy — Conventional Raman versus spatially offset Raman spectroscopy (SORS). / Nicolson, Fay; Jamieson, Lauren E.; Mabbott, Samuel; Shand, Neil C.; Graham, Duncan; Faulds, Karen.
In: Journal of Raman Spectroscopy, Vol. 48, No. 12, 20.12.2017, p. 1828-1838.Research output: Contribution to journal › Article
TY - JOUR
T1 - Through barrier detection of ethanol using handheld Raman spectroscopy — Conventional Raman versus spatially offset Raman spectroscopy (SORS)
AU - Nicolson, Fay
AU - Jamieson, Lauren E.
AU - Mabbott, Samuel
AU - Shand, Neil C.
AU - Graham, Duncan
AU - Faulds, Karen
N1 - This is the peer reviewed version of the following article: Nicolson, F., Jamieson, L. E., Mabbott, S., Shand, N. C., Graham, D., & Faulds, K. (2017). Through barrier detection of ethanol using handheld Raman spectroscopy—Conventional Raman versus spatially offset Raman spectroscopy (SORS). Journal of Raman Spectroscopy, 48(12), 1828-1838., which has been published in final form at https://doi.org/10.1002/jrs.5258. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
PY - 2017/12/20
Y1 - 2017/12/20
N2 - Spatially offset Raman spectroscopy (SORS) provides chemical analysis at depth even when obscuring barriers such as plastic or tissue are present. As the collection probe is moved further away from the point of laser excitation, scattered photons from deeper layers begin to dominate the acquired spectra, thus giving rise to through barrier detection. Here, we demonstrate the potential of conventional Raman (CR) and SORS for through barrier detection using handheld spectrometers. We report the collection of Raman signals from an ethanol solution through plastic at thicknesses of up to 21 mm using SORS in combination with multivariate analysis. SORS is compared to CR, where we also demonstrate impressive through barrier detection of ethanol at depths up to 9 mm. We also highlight the advantage of applying multivariate analysis for through barrier detection using CR or SORS, particularly when peaks with similar spectral features are present in both the barrier and analyte spectra. In addition, to the best of our knowledge, this is the first report of the assessment of the maximum level of through barrier detection using handheld CR and SORS instruments with a backscattering geometry.
AB - Spatially offset Raman spectroscopy (SORS) provides chemical analysis at depth even when obscuring barriers such as plastic or tissue are present. As the collection probe is moved further away from the point of laser excitation, scattered photons from deeper layers begin to dominate the acquired spectra, thus giving rise to through barrier detection. Here, we demonstrate the potential of conventional Raman (CR) and SORS for through barrier detection using handheld spectrometers. We report the collection of Raman signals from an ethanol solution through plastic at thicknesses of up to 21 mm using SORS in combination with multivariate analysis. SORS is compared to CR, where we also demonstrate impressive through barrier detection of ethanol at depths up to 9 mm. We also highlight the advantage of applying multivariate analysis for through barrier detection using CR or SORS, particularly when peaks with similar spectral features are present in both the barrier and analyte spectra. In addition, to the best of our knowledge, this is the first report of the assessment of the maximum level of through barrier detection using handheld CR and SORS instruments with a backscattering geometry.
KW - conventional Raman
KW - handheld
KW - SORS
KW - through barrier detection
KW - spectroscopy
U2 - 10.1002/jrs.5258
DO - 10.1002/jrs.5258
M3 - Article
VL - 48
SP - 1828
EP - 1838
JO - Journal of Raman Spectroscopy
T2 - Journal of Raman Spectroscopy
JF - Journal of Raman Spectroscopy
SN - 0377-0486
IS - 12
ER -