Three-dimensional fluid pressure mapping in porous media using magnetic resonance imaging with gas-filled liposomes

Robert H. Morris, Martin Bencsik, Anil K. Vangala, Yvonne Perrie

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

This paper presents and demonstrates a method for using magnetic resonance imaging to measure local pressure of a fluid saturating a porous medium. The method is tested both in a static system of packed silica gel and in saturated sintered glass cylinders experiencing fluid flow. The fluid used contains 3% gas in the form of 3-μm average diameter gas filled 1,2-distearoyl-sn-glycero-3-phosphocholine (C18:0, MW: 790.16) liposomes suspended in 5% glycerol and 0.5% Methyl cellulose with water. Preliminary studies at 2.35 T demonstrate relative magnetic resonance signal changes of 20% per bar in bulk fluid for an echo time TE=40 ms, and 6–10% in consolidated porous media for TE=10 ms, over the range 0.8–1.8 bar for a spatial resolution of 0.1 mm3 and a temporal resolution of 30 s. The stability of this solution with relation to applied pressure and methods for improving sensitivity are discussed.
Original languageEnglish
Pages (from-to)509-512
Number of pages4
JournalMagnetic Resonance Imaging
Volume25
Issue number4
DOIs
Publication statusPublished - May 2007

Keywords

  • contrast media
  • gases
  • glass
  • glycerol
  • three-dimensional imaging
  • liposomes
  • Magnetic Resonance Imaging
  • methylcellulose
  • microbubbles
  • permeability
  • phosphatidylcholines
  • porosity
  • pressure
  • silica gel
  • silicon dioxide
  • time factors
  • water

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