Three-dimensional fluid pressure mapping in porous media using magnetic resonance imaging with gas-filled liposomes

Robert H. Morris, Martin Bencsik, Anil K. Vangala, Yvonne Perrie

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

This paper presents and demonstrates a method for using magnetic resonance imaging to measure local pressure of a fluid saturating a porous medium. The method is tested both in a static system of packed silica gel and in saturated sintered glass cylinders experiencing fluid flow. The fluid used contains 3% gas in the form of 3-μm average diameter gas filled 1,2-distearoyl-sn-glycero-3-phosphocholine (C18:0, MW: 790.16) liposomes suspended in 5% glycerol and 0.5% Methyl cellulose with water. Preliminary studies at 2.35 T demonstrate relative magnetic resonance signal changes of 20% per bar in bulk fluid for an echo time TE=40 ms, and 6–10% in consolidated porous media for TE=10 ms, over the range 0.8–1.8 bar for a spatial resolution of 0.1 mm3 and a temporal resolution of 30 s. The stability of this solution with relation to applied pressure and methods for improving sensitivity are discussed.
LanguageEnglish
Pages509-512
Number of pages4
JournalMagnetic Resonance Imaging
Volume25
Issue number4
DOIs
Publication statusPublished - May 2007

Fingerprint

fluid pressure
Liposomes
Magnetic resonance
magnetic resonance
Porous materials
Gases
Magnetic Resonance Imaging
Imaging techniques
Pressure
Fluids
fluids
gases
Methylcellulose
Silica Gel
Silica gel
silica gel
glycerols
temporal resolution
Glycerol
cellulose

Keywords

  • contrast media
  • gases
  • glass
  • glycerol
  • three-dimensional imaging
  • liposomes
  • Magnetic Resonance Imaging
  • methylcellulose
  • microbubbles
  • permeability
  • phosphatidylcholines
  • porosity
  • pressure
  • silica gel
  • silicon dioxide
  • time factors
  • water

Cite this

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title = "Three-dimensional fluid pressure mapping in porous media using magnetic resonance imaging with gas-filled liposomes",
abstract = "This paper presents and demonstrates a method for using magnetic resonance imaging to measure local pressure of a fluid saturating a porous medium. The method is tested both in a static system of packed silica gel and in saturated sintered glass cylinders experiencing fluid flow. The fluid used contains 3{\%} gas in the form of 3-μm average diameter gas filled 1,2-distearoyl-sn-glycero-3-phosphocholine (C18:0, MW: 790.16) liposomes suspended in 5{\%} glycerol and 0.5{\%} Methyl cellulose with water. Preliminary studies at 2.35 T demonstrate relative magnetic resonance signal changes of 20{\%} per bar in bulk fluid for an echo time TE=40 ms, and 6–10{\%} in consolidated porous media for TE=10 ms, over the range 0.8–1.8 bar for a spatial resolution of 0.1 mm3 and a temporal resolution of 30 s. The stability of this solution with relation to applied pressure and methods for improving sensitivity are discussed.",
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Three-dimensional fluid pressure mapping in porous media using magnetic resonance imaging with gas-filled liposomes. / Morris, Robert H.; Bencsik, Martin; Vangala, Anil K.; Perrie, Yvonne.

In: Magnetic Resonance Imaging, Vol. 25, No. 4, 05.2007, p. 509-512.

Research output: Contribution to journalArticle

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N2 - This paper presents and demonstrates a method for using magnetic resonance imaging to measure local pressure of a fluid saturating a porous medium. The method is tested both in a static system of packed silica gel and in saturated sintered glass cylinders experiencing fluid flow. The fluid used contains 3% gas in the form of 3-μm average diameter gas filled 1,2-distearoyl-sn-glycero-3-phosphocholine (C18:0, MW: 790.16) liposomes suspended in 5% glycerol and 0.5% Methyl cellulose with water. Preliminary studies at 2.35 T demonstrate relative magnetic resonance signal changes of 20% per bar in bulk fluid for an echo time TE=40 ms, and 6–10% in consolidated porous media for TE=10 ms, over the range 0.8–1.8 bar for a spatial resolution of 0.1 mm3 and a temporal resolution of 30 s. The stability of this solution with relation to applied pressure and methods for improving sensitivity are discussed.

AB - This paper presents and demonstrates a method for using magnetic resonance imaging to measure local pressure of a fluid saturating a porous medium. The method is tested both in a static system of packed silica gel and in saturated sintered glass cylinders experiencing fluid flow. The fluid used contains 3% gas in the form of 3-μm average diameter gas filled 1,2-distearoyl-sn-glycero-3-phosphocholine (C18:0, MW: 790.16) liposomes suspended in 5% glycerol and 0.5% Methyl cellulose with water. Preliminary studies at 2.35 T demonstrate relative magnetic resonance signal changes of 20% per bar in bulk fluid for an echo time TE=40 ms, and 6–10% in consolidated porous media for TE=10 ms, over the range 0.8–1.8 bar for a spatial resolution of 0.1 mm3 and a temporal resolution of 30 s. The stability of this solution with relation to applied pressure and methods for improving sensitivity are discussed.

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