TY - JOUR
T1 - Three-dimensional bioprinting of stem-cell derived tissues for human regenerative medicine
AU - Skeldon, Gregor
AU - Lucendo-Villarin, Baltasar
AU - Shu, Wenmiao
N1 - This article is part of the theme issue 'Designer human tissue: coming to a lab near you'.
PY - 2018/7/5
Y1 - 2018/7/5
N2 - Stem cell technology in regenerative medicine has the potential to provide an unlimited supply of cells for drug testing, medical transplantation and aca-demic research. In order to engineer a realistic tissue model using stem cells as an alternative to human tissue, it is essential to create artificial stem cell microenvironment or niches. Three-dimensional (3D) bioprinting is a promising tissue engineering field that offers new opportunities to precisely place stem cells within their niches layer-by-layer. This review covers bioprinting technologies, the current development of 'bio-inks' and how bioprinting has already been applied to stem-cell culture, as well as their applications for human regenerative medicine. The key considerations for bioink properties such as stiffness, stability and biodegradation, biocompatibility and print- ability are highlighted. Bioprinting of both adult and pluriopotent stem cells for various types of artificial tissues from liver to brain has been reviewed. 3D bioprinting of stem-cell derived tissues for human regenerative medicine is an exciting emerging area that represents opportunities for new research, industries and products as well as future challenges in clinical translation.
AB - Stem cell technology in regenerative medicine has the potential to provide an unlimited supply of cells for drug testing, medical transplantation and aca-demic research. In order to engineer a realistic tissue model using stem cells as an alternative to human tissue, it is essential to create artificial stem cell microenvironment or niches. Three-dimensional (3D) bioprinting is a promising tissue engineering field that offers new opportunities to precisely place stem cells within their niches layer-by-layer. This review covers bioprinting technologies, the current development of 'bio-inks' and how bioprinting has already been applied to stem-cell culture, as well as their applications for human regenerative medicine. The key considerations for bioink properties such as stiffness, stability and biodegradation, biocompatibility and print- ability are highlighted. Bioprinting of both adult and pluriopotent stem cells for various types of artificial tissues from liver to brain has been reviewed. 3D bioprinting of stem-cell derived tissues for human regenerative medicine is an exciting emerging area that represents opportunities for new research, industries and products as well as future challenges in clinical translation.
KW - stem cells
KW - human tissue
KW - human regenerative medicine
KW - bioprinting
U2 - 10.1098/rstb.2017.0224
DO - 10.1098/rstb.2017.0224
M3 - Article
SN - 0962-8436
VL - 373
JO - Philosophical Transactions B: Biological Sciences
JF - Philosophical Transactions B: Biological Sciences
M1 - 20170224
ER -