Thermally triggered theranostics for pancreatic cancer therapy

Maryam Malekigorji, Mohanad Alfahad, Paul Kong Thoo Lin, Stephanie Jones, Anthony Curtis, Clare Hoskins

Research output: Contribution to journalArticle

17 Citations (Scopus)
1 Downloads (Pure)

Abstract

Hybrid iron oxide–gold nanoparticles (HNPs) show the ability to bind drugs onto their surface with a triggered release at elevated temperatures. The iron oxide core allows for diagnostic imaging whilst heating of the gold shell upon laser irradiation reverses drug binding. This study exploits the reversible binding of novel polyamine based drugs in order to provide a specific and effective method for pancreatic cancer treatment. Here we used a novel bisnaphthalamido (BNIP) based drug series. Our hybrid nanoparticles (50 nm) showed the ability to load drugs onto their surface (3 : 1 : 0.25, drug : Fe : Au). By exploiting the surface-to-drug electrostatic interaction of a range of BNIP agents, heat triggered drug release was achieved. A 12-fold reduction in IC50 after 24 h in vitro and a 5-fold reduction of tumour retardation in vivo compared with free drug in pancreatic models after treatment were achieved with the HNP-formulation and laser irradiation. This heat activated system could provide a key platform for future therapeutic strategies.
Original languageEnglish
Pages (from-to)12735–12745
Number of pages11
JournalNanoscale
Volume9
Issue number34
DOIs
Publication statusPublished - 3 Aug 2017

Keywords

  • theranostic
  • laser irradiation
  • thermo-responsive drug delivery
  • pancreatic cancer

Fingerprint Dive into the research topics of 'Thermally triggered theranostics for pancreatic cancer therapy'. Together they form a unique fingerprint.

  • Cite this

    Malekigorji, M., Alfahad, M., Kong Thoo Lin, P., Jones, S., Curtis, A., & Hoskins, C. (2017). Thermally triggered theranostics for pancreatic cancer therapy. Nanoscale, 9(34), 12735–12745. https://doi.org/10.1039/C7NR02751F