TY - JOUR
T1 - Thermal investigation into the interaction of cetostearyl alcohol and a cetostearyl alcohol/sodium lauryl sulphate mixed emulsifier with liquid paraffin
AU - Rouse, J.J.
AU - Kim, J.H.
AU - Lawrence, M.J.
AU - Eccleston, G.M.
PY - 2008
Y1 - 2008
N2 - In previous work, mobile nanoemulsions were prepared by the
ultrasonication of liquid paraffin (LP) in water macroemulsions containing the
mixed emulsifier (ME) sodium lauryl sulphate (SLS) and cetostearyl alcohol
(CSA; Kim et al 2007). It was shown that the lamellar gel networks, formed when
the ME interacts with water (ternary system), were not present in freshly prepared
nanoemulsions. In these systems, the endotherm associated with the lamellar phase
was absent and replaced by a prominent, broad unidentified endotherm between
50 and 60C. The aim of this work was to identify the nature of this endotherm to
gain a better understanding of nanoemulsion microstructure. To this end, the
interactions of the ME and its components in oil were investigated.
AB - In previous work, mobile nanoemulsions were prepared by the
ultrasonication of liquid paraffin (LP) in water macroemulsions containing the
mixed emulsifier (ME) sodium lauryl sulphate (SLS) and cetostearyl alcohol
(CSA; Kim et al 2007). It was shown that the lamellar gel networks, formed when
the ME interacts with water (ternary system), were not present in freshly prepared
nanoemulsions. In these systems, the endotherm associated with the lamellar phase
was absent and replaced by a prominent, broad unidentified endotherm between
50 and 60C. The aim of this work was to identify the nature of this endotherm to
gain a better understanding of nanoemulsion microstructure. To this end, the
interactions of the ME and its components in oil were investigated.
KW - cetostearyl alcohol
KW - cetostearyl alcohol/sodium lauryl sulphate
KW - thermal investigation
U2 - 10.1211/002235708785623327
DO - 10.1211/002235708785623327
M3 - Article
SN - 0022-3573
VL - 60
SP - A61-A61
JO - Journal of Pharmacy and Pharmacology
JF - Journal of Pharmacy and Pharmacology
IS - S1
ER -