There's NO stopping NsrR, a global regulator of the bacterial NO stress response

N.P. Tucker; N.E. Le Brun; R. Dixon; M.I. Hutchings

doi:10.1016/j.tim.2009.12.009

There's NO stopping NsrR, a global regulator of the bacterial NO stress response

N.P. Tucker, N.E. Le Brun, R. Dixon, M.I. Hutchings

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

109 Citations (Scopus)

Abstract

Nitric oxide (NO) is a toxic, free radical gas with diverse biological roles in eukaryotes and bacteria, being involved in signalling, vasodilation, blood clotting and immunity and as an intermediate in microbial denitrification. Several bacterial transcriptional regulators sense this molecule and regulate the expression of genes involved in both NO detoxification and NO damage repair. However, a recently discovered NO sensing repressor, named NsrR, has gained attention because of its suggested role as a global regulator of the bacterial NO stress response. Recent advances in biochemical and transcriptomic studies of NsrR make it timely to review the current evidence for NsrR as a global regulator and to speculate on the recent controversy over its NO sensing mechanism.

Original language	English
Pages (from-to)	149-159
Number of pages	11
Journal	Trends in Microbiology
Volume	18
Issue number	4
DOIs	https://doi.org/10.1016/j.tim.2009.12.009
Publication status	Published - 16 Apr 2009

Keywords

microbiology
nitric oxide
NO

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.tim.2009.12.009

Analysis of free radicals, radical modifications and redox signalling
Tucker, N. (Invited speaker)
18 Apr 2011 → 19 Apr 2011
Activity: Participating in or organising an event types › Key-note speaker and plenary lectures at conferences

Cite this

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title = "There's NO stopping NsrR, a global regulator of the bacterial NO stress response",

abstract = "Nitric oxide (NO) is a toxic, free radical gas with diverse biological roles in eukaryotes and bacteria, being involved in signalling, vasodilation, blood clotting and immunity and as an intermediate in microbial denitrification. Several bacterial transcriptional regulators sense this molecule and regulate the expression of genes involved in both NO detoxification and NO damage repair. However, a recently discovered NO sensing repressor, named NsrR, has gained attention because of its suggested role as a global regulator of the bacterial NO stress response. Recent advances in biochemical and transcriptomic studies of NsrR make it timely to review the current evidence for NsrR as a global regulator and to speculate on the recent controversy over its NO sensing mechanism.",

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AU - Tucker, N.P.

AU - Le Brun, N.E.

AU - Dixon, R.

AU - Hutchings, M.I.

PY - 2009/4/16

Y1 - 2009/4/16

N2 - Nitric oxide (NO) is a toxic, free radical gas with diverse biological roles in eukaryotes and bacteria, being involved in signalling, vasodilation, blood clotting and immunity and as an intermediate in microbial denitrification. Several bacterial transcriptional regulators sense this molecule and regulate the expression of genes involved in both NO detoxification and NO damage repair. However, a recently discovered NO sensing repressor, named NsrR, has gained attention because of its suggested role as a global regulator of the bacterial NO stress response. Recent advances in biochemical and transcriptomic studies of NsrR make it timely to review the current evidence for NsrR as a global regulator and to speculate on the recent controversy over its NO sensing mechanism.

AB - Nitric oxide (NO) is a toxic, free radical gas with diverse biological roles in eukaryotes and bacteria, being involved in signalling, vasodilation, blood clotting and immunity and as an intermediate in microbial denitrification. Several bacterial transcriptional regulators sense this molecule and regulate the expression of genes involved in both NO detoxification and NO damage repair. However, a recently discovered NO sensing repressor, named NsrR, has gained attention because of its suggested role as a global regulator of the bacterial NO stress response. Recent advances in biochemical and transcriptomic studies of NsrR make it timely to review the current evidence for NsrR as a global regulator and to speculate on the recent controversy over its NO sensing mechanism.

KW - microbiology

KW - nitric oxide

KW - NO

U2 - 10.1016/j.tim.2009.12.009

DO - 10.1016/j.tim.2009.12.009

M3 - Article

SN - 0966-842X

VL - 18

SP - 149

EP - 159

JO - Trends in Microbiology

JF - Trends in Microbiology

IS - 4

ER -

There's NO stopping NsrR, a global regulator of the bacterial NO stress response

Abstract

Keywords

UN SDGs

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Activities

Analysis of free radicals, radical modifications and redox signalling

Cite this