Theoretical and experimental characterisation of magnetic microbubbles

Helen Mulvana, Robert J. Eckersley, Meng-xing Tang, Quentin Pankhurst, Eleanor Stride

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

In addition to improving image contrast, microbubbles have shown great potential in molecular imaging and drug/gene delivery. Previous work by the authors showed that considerable improvements in gene transfection efficiency were obtained using microbubbles loaded with magnetic nanoparticles under simultaneous exposure to ultrasound and magnetic fields. The aim of this study was to characterise the effect of nanoparticles on the dynamic and acoustic response of the microbubbles. High-speed video microscopy indicated that the amplitude of oscillation was very similar for magnetic and nonmagnetic microbubbles of the same size for the same ultrasound exposure (0.5 MHz, 100 kPa, 12-cycle pulse) and that this was minimally affected by an imposed magnetic field. The linear scattering to attenuation ratio (STAR) was also similar for suspensions of both bubble types although the nonlinear STAR was ∼50% lower for the magnetic microbubbles. Both the video and acoustic data were supported by the results from theoretical modelling.
Original languageEnglish
Pages (from-to)864-875
Number of pages12
JournalUltrasound in Medicine and Biology
Volume38
Issue number5
Early online date2 Apr 2012
DOIs
Publication statusPublished - 31 May 2012

Keywords

  • magnetic microbubbles
  • ultrasound
  • high speed camera
  • magnetic nanoparticles
  • ultrasound contrast agents
  • gene therapy
  • drug delivery

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