The zDHHC family of S-acyltransferases

Kimon Lemonidis, Martin W. Werno, Jennifer Greaves, Cinta Diez Ardanuy, Maria C. Sanchez Perez, Christine Salaun, David M. Thomson, Luke H. Chamberlain

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The discovery of the zDHHC family of S-acyltransferase enzymes has been one of the major breakthroughs in the S-acylation field. Now, more than a decade since their discovery, major questions centre on profiling the substrates of individual zDHHC enzymes (there are 24 ZDHHC genes and several hundred S-acylated proteins), defining the mechanisms of enzyme-substrate specificity and unravelling the importance of this enzyme family for cellular physiology and pathology.
LanguageEnglish
Pages217-221
Number of pages5
JournalBiochemical Society Transactions
Volume43
Issue number2
DOIs
Publication statusPublished - Apr 2015

Fingerprint

Acyltransferases
Enzymes
Acylation
Protein S
Physiology
Pathology
Substrates
Substrate Specificity
Genes
Proteins

Keywords

  • palmitoylation zDHHC enzymes
  • S-acylation
  • thioesterases

Cite this

Lemonidis, K., Werno, M. W., Greaves, J., Diez Ardanuy, C., Sanchez Perez, M. C., Salaun, C., ... Chamberlain, L. H. (2015). The zDHHC family of S-acyltransferases. Biochemical Society Transactions, 43(2), 217-221. https://doi.org/10.1042/BST20140270
Lemonidis, Kimon ; Werno, Martin W. ; Greaves, Jennifer ; Diez Ardanuy, Cinta ; Sanchez Perez, Maria C. ; Salaun, Christine ; Thomson, David M. ; Chamberlain, Luke H. / The zDHHC family of S-acyltransferases. In: Biochemical Society Transactions. 2015 ; Vol. 43, No. 2. pp. 217-221.
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Lemonidis, K, Werno, MW, Greaves, J, Diez Ardanuy, C, Sanchez Perez, MC, Salaun, C, Thomson, DM & Chamberlain, LH 2015, 'The zDHHC family of S-acyltransferases' Biochemical Society Transactions, vol. 43, no. 2, pp. 217-221. https://doi.org/10.1042/BST20140270

The zDHHC family of S-acyltransferases. / Lemonidis, Kimon; Werno, Martin W.; Greaves, Jennifer; Diez Ardanuy, Cinta; Sanchez Perez, Maria C.; Salaun, Christine; Thomson, David M.; Chamberlain, Luke H.

In: Biochemical Society Transactions, Vol. 43, No. 2, 04.2015, p. 217-221.

Research output: Contribution to journalArticle

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Lemonidis K, Werno MW, Greaves J, Diez Ardanuy C, Sanchez Perez MC, Salaun C et al. The zDHHC family of S-acyltransferases. Biochemical Society Transactions. 2015 Apr;43(2):217-221. https://doi.org/10.1042/BST20140270