The zDHHC family of S-acyltransferases

Kimon Lemonidis, Martin W. Werno, Jennifer Greaves, Cinta Diez Ardanuy, Maria C. Sanchez Perez, Christine Salaun, David M. Thomson, Luke H. Chamberlain

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)
225 Downloads (Pure)


The discovery of the zDHHC family of S-acyltransferase enzymes has been one of the major breakthroughs in the S-acylation field. Now, more than a decade since their discovery, major questions centre on profiling the substrates of individual zDHHC enzymes (there are 24 ZDHHC genes and several hundred S-acylated proteins), defining the mechanisms of enzyme-substrate specificity and unravelling the importance of this enzyme family for cellular physiology and pathology.
Original languageEnglish
Pages (from-to)217-221
Number of pages5
JournalBiochemical Society Transactions
Issue number2
Publication statusPublished - Apr 2015


  • palmitoylation zDHHC enzymes
  • S-acylation
  • thioesterases


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