The zDHHC family of S-acyltransferases

Kimon Lemonidis; Martin W. Werno; Jennifer Greaves; Cinta Diez Ardanuy; Maria C. Sanchez Perez; Christine Salaun; David M. Thomson; Luke H. Chamberlain

doi:10.1042/BST20140270

The zDHHC family of S-acyltransferases

Kimon Lemonidis, Martin W. Werno, Jennifer Greaves, Cinta Diez Ardanuy, Maria C. Sanchez Perez, Christine Salaun, David M. Thomson, Luke H. Chamberlain

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Abstract

The discovery of the zDHHC family of S-acyltransferase enzymes has been one of the major breakthroughs in the S-acylation field. Now, more than a decade since their discovery, major questions centre on profiling the substrates of individual zDHHC enzymes (there are 24 ZDHHC genes and several hundred S-acylated proteins), defining the mechanisms of enzyme-substrate specificity and unravelling the importance of this enzyme family for cellular physiology and pathology.

Original language	English
Pages (from-to)	217-221
Number of pages	5
Journal	Biochemical Society Transactions
Volume	43
Issue number	2
DOIs	https://doi.org/10.1042/BST20140270
Publication status	Published - Apr 2015

Keywords

palmitoylation zDHHC enzymes
S-acylation
thioesterases

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The zDHHC family of S-acyltransferases BST_2015_author final versionAccepted author manuscript, 432 KB

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AU - Salaun, Christine

AU - Thomson, David M.

AU - Chamberlain, Luke H.

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AB - The discovery of the zDHHC family of S-acyltransferase enzymes has been one of the major breakthroughs in the S-acylation field. Now, more than a decade since their discovery, major questions centre on profiling the substrates of individual zDHHC enzymes (there are 24 ZDHHC genes and several hundred S-acylated proteins), defining the mechanisms of enzyme-substrate specificity and unravelling the importance of this enzyme family for cellular physiology and pathology.

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KW - S-acylation

KW - thioesterases

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JF - Biochemical Society Transactions

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ER -

The zDHHC family of S-acyltransferases

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Keywords

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