The vitreous humor as a barrier to nanoparticle distribution

Jenifer Mains, Clive Wilson

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

The vitreous humor represents a significant barrier to the penetration of nanoparticulate-based ocular drug delivery systems. The gel structure and biochemical components of the vitreous will impact on the rate of nanoparticle movement through the tissue to reach the retinal tissue. As well as structure of the vitreous, flow systems operating within the vitreous, age-related structural changes, and the presence of inflammation will also have a potential effect on movement. To effectively target the posterior retina, the physical properties of the nanoparticle formulation are a key element in the design of a system that will penetrate through the vitreous barrier.
Original languageEnglish
Number of pages8
Journal Journal of Ocular Pharmacology and Therapeutics
Early online date31 Oct 2012
DOIs
Publication statusE-pub ahead of print - 31 Oct 2012

Keywords

  • ocular drug delivery
  • nanoparticle distribution
  • retinal tissue
  • retinal drug delivery

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