The viscoelastic properties of the vitreous humor measured using an optically trapped local probe

Fiona Watts, Lay Ean Tan, Manlio Tassieri, Niall McAlinden, Clive Wilson, John Girkin, Amanda Wright

Research output: Contribution to conferenceProceeding

3 Citations (Scopus)

Abstract

We present results demonstrating for the first time that an optically trapped bead can be used as a local probe to measure the variation in the viscoelastic properties of the vitreous humor of a rabbit eye. The Brownian motion of the optically trapped bead was monitored on a fast CCD camera on the millisecond timescale. Analysis of the bead trajectory provides local information about the viscoelastic properties of the medium surrounding the particle. Previous, bulk, methods for measuring the viscoelastic properties of the vitreous destroy the sample and allow only a single averaged measurement to be taken per eye. Whereas, with our approach, we were able to observe local behaviour typical of non-Newtonian and gel-like materials, along with the homogenous and in-homogeneous nature of different regions of the dissected vitreous humor. The motivation behind these measurements is to gain a better understanding of the structure of the vitreous humor in order to design effective drug delivery techniques. In particular, we are interested in methods for delivering drug to the retina of the eye in order to treat sight threatening diseases such as age related macular degeneration.
Original languageEnglish
Pages80970H
DOIs
Publication statusPublished - 2011
EventSPIE Optics and Photonics - San Diego, United States
Duration: 21 Aug 201125 Aug 2011

Conference

ConferenceSPIE Optics and Photonics
CountryUnited States
CitySan Diego
Period21/08/1125/08/11

Fingerprint

beads
probes
drugs
degeneration
retina
rabbits
visual perception
CCD cameras
delivery
trajectories
gels

Keywords

  • viscoelastic properties
  • vitreous humor
  • optics

Cite this

Watts, F., Tan, L. E., Tassieri, M., McAlinden, N., Wilson, C., Girkin, J., & Wright, A. (2011). The viscoelastic properties of the vitreous humor measured using an optically trapped local probe. 80970H. SPIE Optics and Photonics, San Diego, United States. https://doi.org/10.1117/12.895192
Watts, Fiona ; Tan, Lay Ean ; Tassieri, Manlio ; McAlinden, Niall ; Wilson, Clive ; Girkin, John ; Wright, Amanda. / The viscoelastic properties of the vitreous humor measured using an optically trapped local probe. SPIE Optics and Photonics, San Diego, United States.
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Watts, F, Tan, LE, Tassieri, M, McAlinden, N, Wilson, C, Girkin, J & Wright, A 2011, 'The viscoelastic properties of the vitreous humor measured using an optically trapped local probe' SPIE Optics and Photonics, San Diego, United States, 21/08/11 - 25/08/11, pp. 80970H. https://doi.org/10.1117/12.895192

The viscoelastic properties of the vitreous humor measured using an optically trapped local probe. / Watts, Fiona; Tan, Lay Ean; Tassieri, Manlio; McAlinden, Niall; Wilson, Clive; Girkin, John; Wright, Amanda.

2011. 80970H SPIE Optics and Photonics, San Diego, United States.

Research output: Contribution to conferenceProceeding

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AU - Tan, Lay Ean

AU - Tassieri, Manlio

AU - McAlinden, Niall

AU - Wilson, Clive

AU - Girkin, John

AU - Wright, Amanda

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Watts F, Tan LE, Tassieri M, McAlinden N, Wilson C, Girkin J et al. The viscoelastic properties of the vitreous humor measured using an optically trapped local probe. 2011. SPIE Optics and Photonics, San Diego, United States. https://doi.org/10.1117/12.895192