The unusual mitochondrial compartment of Cryptosporidium parvum

F L Henriquez, T A Richards, F Roberts, R McLeod, C W Roberts

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Recent studies, including the Cryptosporidium parvum Genome Project, have provided evidence for a mitochondrial-derived compartment in this parasite. This organelle appears to lack a genome, and thus must be entirely dependent on nuclear-encoded proteins. Here, we review the evidence for such an organelle in C. parvum and its probable function. There is no adequate treatment for infection by this parasite and so the elucidation of the role of this organelle and the effective targeting of its functions by antimicrobial agents might provide new treatments for infection by C. parvum.

LanguageEnglish
Pages68-74
Number of pages7
JournalTrends in Parasitology
Volume21
Issue number2
DOIs
Publication statusPublished - Feb 2005

Fingerprint

Cryptosporidium parvum
Organelles
Genome
Parasitic Diseases
Nuclear Proteins
Anti-Infective Agents
Parasites
Infection

Keywords

  • plastid terminal oxidase
  • alternative oxidase
  • trichomonas-vaginalis
  • therapeutic implications
  • giardia-intestinalis
  • proton translocation
  • targeting sequences
  • protein importq
  • gene iscs
  • apicomplexan

Cite this

Henriquez, F L ; Richards, T A ; Roberts, F ; McLeod, R ; Roberts, C W . / The unusual mitochondrial compartment of Cryptosporidium parvum. In: Trends in Parasitology. 2005 ; Vol. 21, No. 2. pp. 68-74.
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The unusual mitochondrial compartment of Cryptosporidium parvum. / Henriquez, F L ; Richards, T A ; Roberts, F ; McLeod, R ; Roberts, C W .

In: Trends in Parasitology, Vol. 21, No. 2, 02.2005, p. 68-74.

Research output: Contribution to journalArticle

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KW - targeting sequences

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