The toxicity of troglitazone, roziglitazone and vitamin e in human hep g2 hepatoma cells

A.J. Ball, J.N.A. Tettey, M.H. Grant

Research output: Contribution to journalConference Contribution

Abstract

Troglitazone (TGZ), a member of the thiazolidinedione class of drugs used to treat type-II diabetes, has been associated with hepatotoxicity (Biswas et al., 2001). TGZ differs structurally from the newer non-hepatotoxic glitazone, rosiglitazone (RGZ), in that it contains the chromanol moiety of Vitamin E (Vit E). This study compares
the toxicity of TGZ, RGZ and Vit E in human HepG2 cells
LanguageEnglish
Pages250-251
Number of pages2
JournalToxicology
Volume194
Issue number3
DOIs
Publication statusPublished - 2004

Fingerprint

troglitazone
rosiglitazone
Hep G2 Cells
Vitamins
Toxicity
Hepatocellular Carcinoma
Vitamin E
Thiazolidinediones
Medical problems
Type 2 Diabetes Mellitus
Pharmaceutical Preparations

Keywords

  • troglitazone
  • roziglitazone
  • toxiciology

Cite this

Ball, A.J. ; Tettey, J.N.A. ; Grant, M.H. / The toxicity of troglitazone, roziglitazone and vitamin e in human hep g2 hepatoma cells. In: Toxicology. 2004 ; Vol. 194, No. 3. pp. 250-251.
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The toxicity of troglitazone, roziglitazone and vitamin e in human hep g2 hepatoma cells. / Ball, A.J.; Tettey, J.N.A.; Grant, M.H.

In: Toxicology, Vol. 194, No. 3, 2004, p. 250-251.

Research output: Contribution to journalConference Contribution

TY - JOUR

T1 - The toxicity of troglitazone, roziglitazone and vitamin e in human hep g2 hepatoma cells

AU - Ball, A.J.

AU - Tettey, J.N.A.

AU - Grant, M.H.

N1 - Abstracts of the British Toxicology Society Annual Congress 2003.

PY - 2004

Y1 - 2004

N2 - Troglitazone (TGZ), a member of the thiazolidinedione class of drugs used to treat type-II diabetes, has been associated with hepatotoxicity (Biswas et al., 2001). TGZ differs structurally from the newer non-hepatotoxic glitazone, rosiglitazone (RGZ), in that it contains the chromanol moiety of Vitamin E (Vit E). This study comparesthe toxicity of TGZ, RGZ and Vit E in human HepG2 cells

AB - Troglitazone (TGZ), a member of the thiazolidinedione class of drugs used to treat type-II diabetes, has been associated with hepatotoxicity (Biswas et al., 2001). TGZ differs structurally from the newer non-hepatotoxic glitazone, rosiglitazone (RGZ), in that it contains the chromanol moiety of Vitamin E (Vit E). This study comparesthe toxicity of TGZ, RGZ and Vit E in human HepG2 cells

KW - troglitazone

KW - roziglitazone

KW - toxiciology

U2 - 10.1016/j.tox.2003.09.003

DO - 10.1016/j.tox.2003.09.003

M3 - Conference Contribution

VL - 194

SP - 250

EP - 251

JO - Toxicology

T2 - Toxicology

JF - Toxicology

SN - 0300-483X

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