The Synthesis of Cyclic Ether-Containing Natural and Non-natural Products by Metathesis Reactions

David M. Lindsay

doi:10.1007/7081_2015_197

The Synthesis of Cyclic Ether-Containing Natural and Non-natural Products by Metathesis Reactions

David M. Lindsay

Pure And Applied Chemistry

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

This chapter describes recent advances (2005–2015) in the use of metathesis reactions to construct the cyclic ether portions in the total synthesis of natural products. Advances in the synthesis of a range of marine polyether natural products are presented, and various strategic approaches to the bridged pyranmacrocycles neopeltolide and kendomycin are discussed. Finally, the synthesis of a range of biologically active, cyclic ether-based non-natural products is described.

Original language	English
Title of host publication	Topics in Heterocyclic Chemistry
Editors	J. Prunet
Place of Publication	Cham
Publisher	Springer
Chapter	2
Pages	33-56
Number of pages	24
ISBN (Print)	9783319399393, 9783319399416
DOIs	https://doi.org/10.1007/7081_2015_197
Publication status	Published - 3 Feb 2016

Keywords

bioactive compounds
cyclisation
ether
metathesis reactions
natural products

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10.1007/7081_2015_197

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abstract = "This chapter describes recent advances (2005–2015) in the use of metathesis reactions to construct the cyclic ether portions in the total synthesis of natural products. Advances in the synthesis of a range of marine polyether natural products are presented, and various strategic approaches to the bridged pyranmacrocycles neopeltolide and kendomycin are discussed. Finally, the synthesis of a range of biologically active, cyclic ether-based non-natural products is described.",

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AB - This chapter describes recent advances (2005–2015) in the use of metathesis reactions to construct the cyclic ether portions in the total synthesis of natural products. Advances in the synthesis of a range of marine polyether natural products are presented, and various strategic approaches to the bridged pyranmacrocycles neopeltolide and kendomycin are discussed. Finally, the synthesis of a range of biologically active, cyclic ether-based non-natural products is described.

KW - bioactive compounds

KW - cyclisation

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KW - metathesis reactions

KW - natural products

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CY - Cham

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The Synthesis of Cyclic Ether-Containing Natural and Non-natural Products by Metathesis Reactions

Abstract

Keywords

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