This chapter describes recent advances (2005–2015) in the use of metathesis reactions to construct the cyclic ether portions in the total synthesis of natural products. Advances in the synthesis of a range of marine polyether natural products are presented, and various strategic approaches to the bridged pyranmacrocycles neopeltolide and kendomycin are discussed. Finally, the synthesis of a range of biologically active, cyclic ether-based non-natural products is described.
- bioactive compounds
- metathesis reactions
- natural products
Lindsay, D. M. (2016). The Synthesis of Cyclic Ether-Containing Natural and Non-natural Products by Metathesis Reactions. In J. Prunet (Ed.), Topics in Heterocyclic Chemistry (pp. 33-56). Springer. https://doi.org/10.1007/7081_2015_197