The synthesis of chiral annulet 1,4,7-triazacyclononanes

G. Argouarch, C.L. Gibson, G. Stones, D.C. Sherrington

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Abstract

Novel and flexible routes for the synthesis of chiral ring annulet 2,6-disubstituted 1,4,7-trimethyl-1,4,7-triazamacrocycles are described. Efficient macrocyclisations were realised provided that chiral analogues of N,N-bis-[2-(toluene-sulfonyl-amino)ethyl]-toluene-4-sulfonamide were used as the nueleophilic components. Complexes prepared, in situ, from these 2,6-disubstituted 1,4,7-timethyl-1,4,7-triazamacrocycles and manganese(II) catalysed the asymmetric epoxidation of styrene with hydrogen peroxide.
Original languageEnglish
Pages (from-to)3795-3798
Number of pages3
JournalTetrahedron Letters
Volume43
Issue number21
DOIs
Publication statusPublished - 20 May 2002

Keywords

  • asymmetric synthesis
  • epoxidation
  • polyamines

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    Argouarch, G., Gibson, C. L., Stones, G., & Sherrington, D. C. (2002). The synthesis of chiral annulet 1,4,7-triazacyclononanes. Tetrahedron Letters, 43(21), 3795-3798. https://doi.org/10.1016/S0040-4039(02)00705-0