Abstract
Using L-valine methyl ester hydrochloride as starting material, the synthesis of ( 2S)- 2- isopropyl- 1,4,7- trimethyl-1,4,7- triazacyclononane is described. Various standard Richman - Atkins cyclisation methods gave only poor yields in the key macrocyclisation step. Efficient macrocyclisation yields were, however, realised when an in situ sequential cyclisation method was developed.
| Original language | English |
|---|---|
| Pages (from-to) | 2357-2363 |
| Number of pages | 6 |
| Journal | Organic and Biomolecular Chemistry |
| Volume | 1 |
| Issue number | 13 |
| DOIs | |
| Publication status | Published - 22 May 2003 |
Keywords
- HIGHLY SELECTIVE EPOXIDATION
- MANGANESE COMPLEXES
- OLEFIN EPOXIDATION
- CHIRAL AZIRIDINES
- LIGANDS
- TRIAZACYCLONONANE
- OXIDATION
- CATALYSTS
- H2O2
- ACID
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