The synthesis of an isopropyl substituted 1,4,7-triazacyclononane via an in situ sequential macrocyclisation method

G. Stones, G. Argouarch, A.R. Kennedy, D.C. Sherrington, C.L. Gibson

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Using L-valine methyl ester hydrochloride as starting material, the synthesis of ( 2S)- 2- isopropyl- 1,4,7- trimethyl-1,4,7- triazacyclononane is described. Various standard Richman - Atkins cyclisation methods gave only poor yields in the key macrocyclisation step. Efficient macrocyclisation yields were, however, realised when an in situ sequential cyclisation method was developed.
Original languageEnglish
Pages (from-to)2357-2363
Number of pages6
JournalOrganic and Biomolecular Chemistry
Volume1
Issue number13
DOIs
Publication statusPublished - 22 May 2003

Keywords

  • HIGHLY SELECTIVE EPOXIDATION
  • MANGANESE COMPLEXES
  • OLEFIN EPOXIDATION
  • CHIRAL AZIRIDINES
  • LIGANDS
  • TRIAZACYCLONONANE
  • OXIDATION
  • CATALYSTS
  • H2O2
  • ACID

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