The synthesis and structure revision of NSC-134754

Jennie A. Hickin, Afshan Ahmed, Katharina Fucke, Margaret Ashcroft, Keith Jones

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)


The synthesis of emetine analogue NSC-134754, a potent inhibitor of the HIF pathway, has been accomplished and its structure reassigned. The stereochemistry of NSC-134754 has been assigned for the first time using X-ray crystallography and it has been demonstrated that only one diastereoisomer is active against HIF. © 2014 The Royal Society of Chemistry.
Original languageEnglish
Pages (from-to)1238-1240
Number of pages3
JournalChemical Communications
Issue number10
Early online date9 Dec 2013
Publication statusPublished - 2014


  • Emetine
  • Stereochemistry
  • X ray crystallography


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