The subiculum: a potential site of ictogenesis in human temporal lobe epilepsy

Christian Wozny, Andreas Knopp, Thomas-Nicolas Lehmann, Uwe Heinemann, Joachim Behr

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

PURPOSE: This study determines synaptic and intrinsic alterations of subicular pyramidal cells that are associated with activity recorded in patients suffering from temporal lobe epilepsy. METHODS: Electroencephalograms with sphenoidal electrodes were correlated with in vitro single cell recordings of subicular pyramidal cells from the corresponding resected epileptic tissue. We determined alterations of synaptic and intrinsic properties of subicular pyramidal cells that accompany spontaneous rhythmic activity in human sclerotic and nonsclerotic epileptic tissue. RESULTS: We found that in sclerotic, but also in nonsclerotic hippocampal tissue, the subiculum showed cellular and synaptic changes that were associated with spontaneous rhythmic activity correlated to the occurrence and frequency of interictal discharges recorded in the electroencephalograms of the corresponding patients. CONCLUSIONS: Even though Ammon's horn sclerosis (AHS) in resected hippocampi from patients suffering from temporal lobe epilepsy has important prognostic implications for freedom from seizures postoperatively, we report here that both synaptic and intrinsic alterations enhance seizure susceptibility of the subiculum also in the absence of classical AHS.
LanguageEnglish
Pages17-21
Number of pages5
JournalEpilepsia
Volume46
Issue numbers5
Early online date29 Jun 2005
DOIs
Publication statusPublished - 1 Jul 2005

Fingerprint

Temporal Lobe Epilepsy
Hippocampus
Pyramidal Cells
Sclerosis
Electroencephalography
Seizures
Human Activities
Electrodes

Keywords

  • adult
  • aged
  • electroencephalography
  • temporal lobe epilepsy
  • hippocampus
  • humans
  • in vitro techniques
  • membrane potentials
  • microelectrodes
  • middle aged
  • pyramidal cells
  • sclerosis
  • synaptic transmission
  • subiculum
  • interictal activity

Cite this

Wozny, Christian ; Knopp, Andreas ; Lehmann, Thomas-Nicolas ; Heinemann, Uwe ; Behr, Joachim. / The subiculum : a potential site of ictogenesis in human temporal lobe epilepsy. In: Epilepsia. 2005 ; Vol. 46, No. s5. pp. 17-21.
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The subiculum : a potential site of ictogenesis in human temporal lobe epilepsy. / Wozny, Christian; Knopp, Andreas; Lehmann, Thomas-Nicolas; Heinemann, Uwe; Behr, Joachim.

In: Epilepsia, Vol. 46, No. s5, 01.07.2005, p. 17-21.

Research output: Contribution to journalArticle

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T2 - Epilepsia

AU - Wozny, Christian

AU - Knopp, Andreas

AU - Lehmann, Thomas-Nicolas

AU - Heinemann, Uwe

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AB - PURPOSE: This study determines synaptic and intrinsic alterations of subicular pyramidal cells that are associated with activity recorded in patients suffering from temporal lobe epilepsy. METHODS: Electroencephalograms with sphenoidal electrodes were correlated with in vitro single cell recordings of subicular pyramidal cells from the corresponding resected epileptic tissue. We determined alterations of synaptic and intrinsic properties of subicular pyramidal cells that accompany spontaneous rhythmic activity in human sclerotic and nonsclerotic epileptic tissue. RESULTS: We found that in sclerotic, but also in nonsclerotic hippocampal tissue, the subiculum showed cellular and synaptic changes that were associated with spontaneous rhythmic activity correlated to the occurrence and frequency of interictal discharges recorded in the electroencephalograms of the corresponding patients. CONCLUSIONS: Even though Ammon's horn sclerosis (AHS) in resected hippocampi from patients suffering from temporal lobe epilepsy has important prognostic implications for freedom from seizures postoperatively, we report here that both synaptic and intrinsic alterations enhance seizure susceptibility of the subiculum also in the absence of classical AHS.

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