The shikimate pathway and its branches in apicomplexan parasites

C W Roberts, F Roberts, R E Lyons, M J Kirisits, E J Mui, J Finnerty, J J Johnson, D J P Ferguson, J R Coggins, T Krell, G H Coombs, W K Milhous, D E Kyle, S Tzipori, J Barnwell, J B Dame, J Carlton, R McLeod, Craig Roberts

Research output: Contribution to journalConference Contribution

110 Citations (Scopus)

Abstract

The shikimate pathway is essential for production of a plethora of aromatic compounds in plants, bacteria, and fungi. Seven enzymes of the shikimate pathway catalyze sequential conversion of erythrose 4-phosphate and phosphoenol pyruvate to chorismate. Chorismate is then used as a substrate for other pathways that culminate in production of folates, ubiquinone, napthoquinones, and the aromatic amino acids tryptophan, phenylalanine, and tyrosine. The shikimate pathway is absent from animals and present in the apicomplexan parasites Toxoplasma gondii, Plasmodium falciparum, and Cryptosporidium parvum. Inhibition of the pathway by glyphosate is effective in controlling growth of these parasites. These findings emphasize the potential benefits of developing additional effective inhibitors of the shikimate pathway. Such inhibitors may function as broad-spectrum antimicrobial agents that are effective against bacterial and fungal pathogens and apicomplexan parasites.

LanguageEnglish
PagesS25-S36
Number of pages12
JournalJournal of Infectious Diseases
Volume185
Issue numberSupplement 1
DOIs
Publication statusPublished - 15 Feb 2002
EventSymposium on Insights on Infection and Immunity - PALO ALTO, United States
Duration: 19 Jan 200119 Jan 2001

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Parasites
glyphosate
Cryptosporidium parvum
Aromatic Amino Acids
Ubiquinone
Toxoplasma
Plasmodium falciparum
Anti-Infective Agents
Pyruvic Acid
Phenylalanine
Folic Acid
Tryptophan
Tyrosine
Fungi
Bacteria
Enzymes
Growth
erythrose 4-phosphate

Keywords

  • 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase
  • escherichia-coli k-12
  • 5-enolpyruvylshikimate 3-PHOSPHATE SYNTHASE
  • saccharomyces-cerevisiae
  • plasmodium-falciparum
  • chorismate synthase
  • herbicide glyphosate
  • toxoplasma-gondii
  • euglena-gracilis
  • EPSP synthase

Cite this

Roberts, C. W., Roberts, F., Lyons, R. E., Kirisits, M. J., Mui, E. J., Finnerty, J., ... Roberts, C. (2002). The shikimate pathway and its branches in apicomplexan parasites. Journal of Infectious Diseases, 185(Supplement 1), S25-S36. https://doi.org/10.1086/338004
Roberts, C W ; Roberts, F ; Lyons, R E ; Kirisits, M J ; Mui, E J ; Finnerty, J ; Johnson, J J ; Ferguson, D J P ; Coggins, J R ; Krell, T ; Coombs, G H ; Milhous, W K ; Kyle, D E ; Tzipori, S ; Barnwell, J ; Dame, J B ; Carlton, J ; McLeod, R ; Roberts, Craig. / The shikimate pathway and its branches in apicomplexan parasites. In: Journal of Infectious Diseases. 2002 ; Vol. 185, No. Supplement 1. pp. S25-S36.
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Roberts, CW, Roberts, F, Lyons, RE, Kirisits, MJ, Mui, EJ, Finnerty, J, Johnson, JJ, Ferguson, DJP, Coggins, JR, Krell, T, Coombs, GH, Milhous, WK, Kyle, DE, Tzipori, S, Barnwell, J, Dame, JB, Carlton, J, McLeod, R & Roberts, C 2002, 'The shikimate pathway and its branches in apicomplexan parasites' Journal of Infectious Diseases, vol. 185, no. Supplement 1, pp. S25-S36. https://doi.org/10.1086/338004

The shikimate pathway and its branches in apicomplexan parasites. / Roberts, C W ; Roberts, F ; Lyons, R E ; Kirisits, M J ; Mui, E J ; Finnerty, J ; Johnson, J J ; Ferguson, D J P ; Coggins, J R ; Krell, T ; Coombs, G H ; Milhous, W K ; Kyle, D E ; Tzipori, S ; Barnwell, J ; Dame, J B ; Carlton, J ; McLeod, R ; Roberts, Craig.

In: Journal of Infectious Diseases, Vol. 185, No. Supplement 1, 15.02.2002, p. S25-S36.

Research output: Contribution to journalConference Contribution

TY - JOUR

T1 - The shikimate pathway and its branches in apicomplexan parasites

AU - Roberts, C W

AU - Roberts, F

AU - Lyons, R E

AU - Kirisits, M J

AU - Mui, E J

AU - Finnerty, J

AU - Johnson, J J

AU - Ferguson, D J P

AU - Coggins, J R

AU - Krell, T

AU - Coombs, G H

AU - Milhous, W K

AU - Kyle, D E

AU - Tzipori, S

AU - Barnwell, J

AU - Dame, J B

AU - Carlton, J

AU - McLeod, R

AU - Roberts, Craig

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N2 - The shikimate pathway is essential for production of a plethora of aromatic compounds in plants, bacteria, and fungi. Seven enzymes of the shikimate pathway catalyze sequential conversion of erythrose 4-phosphate and phosphoenol pyruvate to chorismate. Chorismate is then used as a substrate for other pathways that culminate in production of folates, ubiquinone, napthoquinones, and the aromatic amino acids tryptophan, phenylalanine, and tyrosine. The shikimate pathway is absent from animals and present in the apicomplexan parasites Toxoplasma gondii, Plasmodium falciparum, and Cryptosporidium parvum. Inhibition of the pathway by glyphosate is effective in controlling growth of these parasites. These findings emphasize the potential benefits of developing additional effective inhibitors of the shikimate pathway. Such inhibitors may function as broad-spectrum antimicrobial agents that are effective against bacterial and fungal pathogens and apicomplexan parasites.

AB - The shikimate pathway is essential for production of a plethora of aromatic compounds in plants, bacteria, and fungi. Seven enzymes of the shikimate pathway catalyze sequential conversion of erythrose 4-phosphate and phosphoenol pyruvate to chorismate. Chorismate is then used as a substrate for other pathways that culminate in production of folates, ubiquinone, napthoquinones, and the aromatic amino acids tryptophan, phenylalanine, and tyrosine. The shikimate pathway is absent from animals and present in the apicomplexan parasites Toxoplasma gondii, Plasmodium falciparum, and Cryptosporidium parvum. Inhibition of the pathway by glyphosate is effective in controlling growth of these parasites. These findings emphasize the potential benefits of developing additional effective inhibitors of the shikimate pathway. Such inhibitors may function as broad-spectrum antimicrobial agents that are effective against bacterial and fungal pathogens and apicomplexan parasites.

KW - 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase

KW - escherichia-coli k-12

KW - 5-enolpyruvylshikimate 3-PHOSPHATE SYNTHASE

KW - saccharomyces-cerevisiae

KW - plasmodium-falciparum

KW - chorismate synthase

KW - herbicide glyphosate

KW - toxoplasma-gondii

KW - euglena-gracilis

KW - EPSP synthase

U2 - 10.1086/338004

DO - 10.1086/338004

M3 - Conference Contribution

VL - 185

SP - S25-S36

JO - Journal of Infectious Diseases

T2 - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

IS - Supplement 1

ER -

Roberts CW, Roberts F, Lyons RE, Kirisits MJ, Mui EJ, Finnerty J et al. The shikimate pathway and its branches in apicomplexan parasites. Journal of Infectious Diseases. 2002 Feb 15;185(Supplement 1):S25-S36. https://doi.org/10.1086/338004