Abstract
The shikimate pathway is essential for production of a plethora of aromatic compounds in plants, bacteria, and fungi. Seven enzymes of the shikimate pathway catalyze sequential conversion of erythrose 4-phosphate and phosphoenol pyruvate to chorismate. Chorismate is then used as a substrate for other pathways that culminate in production of folates, ubiquinone, napthoquinones, and the aromatic amino acids tryptophan, phenylalanine, and tyrosine. The shikimate pathway is absent from animals and present in the apicomplexan parasites Toxoplasma gondii, Plasmodium falciparum, and Cryptosporidium parvum. Inhibition of the pathway by glyphosate is effective in controlling growth of these parasites. These findings emphasize the potential benefits of developing additional effective inhibitors of the shikimate pathway. Such inhibitors may function as broad-spectrum antimicrobial agents that are effective against bacterial and fungal pathogens and apicomplexan parasites.
| Language | English |
|---|---|
| Pages | S25-S36 |
| Number of pages | 12 |
| Journal | Journal of Infectious Diseases |
| Volume | 185 |
| Issue number | Supplement 1 |
| DOIs | |
| Publication status | Published - 15 Feb 2002 |
| Event | Symposium on Insights on Infection and Immunity - PALO ALTO, United States Duration: 19 Jan 2001 → 19 Jan 2001 |
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Keywords
- 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase
- escherichia-coli k-12
- 5-enolpyruvylshikimate 3-PHOSPHATE SYNTHASE
- saccharomyces-cerevisiae
- plasmodium-falciparum
- chorismate synthase
- herbicide glyphosate
- toxoplasma-gondii
- euglena-gracilis
- EPSP synthase
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The shikimate pathway and its branches in apicomplexan parasites. / Roberts, C W ; Roberts, F ; Lyons, R E ; Kirisits, M J ; Mui, E J ; Finnerty, J ; Johnson, J J ; Ferguson, D J P ; Coggins, J R ; Krell, T ; Coombs, G H ; Milhous, W K ; Kyle, D E ; Tzipori, S ; Barnwell, J ; Dame, J B ; Carlton, J ; McLeod, R ; Roberts, Craig.
In: Journal of Infectious Diseases, Vol. 185, No. Supplement 1, 15.02.2002, p. S25-S36.Research output: Contribution to journal › Conference Contribution
TY - JOUR
T1 - The shikimate pathway and its branches in apicomplexan parasites
AU - Roberts, C W
AU - Roberts, F
AU - Lyons, R E
AU - Kirisits, M J
AU - Mui, E J
AU - Finnerty, J
AU - Johnson, J J
AU - Ferguson, D J P
AU - Coggins, J R
AU - Krell, T
AU - Coombs, G H
AU - Milhous, W K
AU - Kyle, D E
AU - Tzipori, S
AU - Barnwell, J
AU - Dame, J B
AU - Carlton, J
AU - McLeod, R
AU - Roberts, Craig
PY - 2002/2/15
Y1 - 2002/2/15
N2 - The shikimate pathway is essential for production of a plethora of aromatic compounds in plants, bacteria, and fungi. Seven enzymes of the shikimate pathway catalyze sequential conversion of erythrose 4-phosphate and phosphoenol pyruvate to chorismate. Chorismate is then used as a substrate for other pathways that culminate in production of folates, ubiquinone, napthoquinones, and the aromatic amino acids tryptophan, phenylalanine, and tyrosine. The shikimate pathway is absent from animals and present in the apicomplexan parasites Toxoplasma gondii, Plasmodium falciparum, and Cryptosporidium parvum. Inhibition of the pathway by glyphosate is effective in controlling growth of these parasites. These findings emphasize the potential benefits of developing additional effective inhibitors of the shikimate pathway. Such inhibitors may function as broad-spectrum antimicrobial agents that are effective against bacterial and fungal pathogens and apicomplexan parasites.
AB - The shikimate pathway is essential for production of a plethora of aromatic compounds in plants, bacteria, and fungi. Seven enzymes of the shikimate pathway catalyze sequential conversion of erythrose 4-phosphate and phosphoenol pyruvate to chorismate. Chorismate is then used as a substrate for other pathways that culminate in production of folates, ubiquinone, napthoquinones, and the aromatic amino acids tryptophan, phenylalanine, and tyrosine. The shikimate pathway is absent from animals and present in the apicomplexan parasites Toxoplasma gondii, Plasmodium falciparum, and Cryptosporidium parvum. Inhibition of the pathway by glyphosate is effective in controlling growth of these parasites. These findings emphasize the potential benefits of developing additional effective inhibitors of the shikimate pathway. Such inhibitors may function as broad-spectrum antimicrobial agents that are effective against bacterial and fungal pathogens and apicomplexan parasites.
KW - 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase
KW - escherichia-coli k-12
KW - 5-enolpyruvylshikimate 3-PHOSPHATE SYNTHASE
KW - saccharomyces-cerevisiae
KW - plasmodium-falciparum
KW - chorismate synthase
KW - herbicide glyphosate
KW - toxoplasma-gondii
KW - euglena-gracilis
KW - EPSP synthase
U2 - 10.1086/338004
DO - 10.1086/338004
M3 - Conference Contribution
VL - 185
SP - S25-S36
JO - Journal of Infectious Diseases
T2 - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
SN - 0022-1899
IS - Supplement 1
ER -