Abstract
The sarcoplasmic reticulum (SR) and apposed regions of the sarcolemma passively trap Ca2+ entering the cell to limit the rise in cytoplasmic Ca2+ concentration without SR pump involvement. When "leaky," the SR facilitates Ca2+ entry to the cytoplasm. SR Ca2+ release via inositol 1,4,5-trisphosphate receptors (IP(3)Rs) propagates as calcium waves; IP(3)Rs alone account for wave propagation.
Original language | English |
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Article number | 15143210 |
Pages (from-to) | 138-147 |
Number of pages | 10 |
Journal | News in Physiological Sciences |
Volume | 19 |
DOIs | |
Publication status | Published - Jun 2004 |
Keywords
- inositol 1,4,5-trisphosphate receptors
- cells
- oscillations
- induced calcium-release