The sarcoplasmic reticulum, Ca2+ trapping, and wave mechanisms in smooth muscle

John Mccarron, Karen Bradley, Debbi Macmillan, Susan Chalmers, Thomas C. Muir

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15 Citations (Scopus)


The sarcoplasmic reticulum (SR) and apposed regions of the sarcolemma passively trap Ca2+ entering the cell to limit the rise in cytoplasmic Ca2+ concentration without SR pump involvement. When "leaky," the SR facilitates Ca2+ entry to the cytoplasm. SR Ca2+ release via inositol 1,4,5-trisphosphate receptors (IP(3)Rs) propagates as calcium waves; IP(3)Rs alone account for wave propagation.
Original languageEnglish
Article number15143210
Pages (from-to)138-147
Number of pages10
JournalNews in Physiological Sciences
Publication statusPublished - Jun 2004


  • inositol 1,4,5-trisphosphate receptors
  • cells
  • oscillations
  • induced calcium-release

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