The role of the amino acid residue at α1:189 in the binding of neuromuscular blocking agents to mouse and human muscle nicotinic acetylcholine receptors

P. Gopal, R. Tate, E. Pow, D. Hill, J.G. Connolly

Research output: Contribution to journalArticle

3 Citations (Scopus)


Nicotinic acetylcholine receptors (AChRs) are valuable therapeutic targets. To exploit them fully requires rapid assays for the evaluation of potentially therapeutic ligands and improved understanding of the interaction of such ligands with their receptor binding sites.
Original languageEnglish
Pages (from-to)920-931
Number of pages11
JournalBritish Journal of Pharmacology
Issue number7
Publication statusPublished - 2007


  • nicotinic
  • vecuronium
  • receptor
  • evolution
  • proline
  • phenylalanine
  • serine
  • binding

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