The role of the amino acid residue at α1:189 in the binding of neuromuscular blocking agents to mouse and human muscle nicotinic acetylcholine receptors

P. Gopal; R. Tate; E. Pow; D. Hill; J.G. Connolly

doi:10.1038/sj.bjp.0707156

The role of the amino acid residue at α1:189 in the binding of neuromuscular blocking agents to mouse and human muscle nicotinic acetylcholine receptors

P. Gopal, R. Tate, E. Pow, D. Hill, J.G. Connolly

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Nicotinic acetylcholine receptors (AChRs) are valuable therapeutic targets. To exploit them fully requires rapid assays for the evaluation of potentially therapeutic ligands and improved understanding of the interaction of such ligands with their receptor binding sites.

Original language	English
Pages (from-to)	920-931
Number of pages	11
Journal	British Journal of Pharmacology
Volume	150
Issue number	7
DOIs	https://doi.org/10.1038/sj.bjp.0707156
Publication status	Published - 2007

Keywords

nicotinic
vecuronium
receptor
evolution
proline
phenylalanine
serine
binding

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10.1038/sj.bjp.0707156

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title = "The role of the amino acid residue at α1:189 in the binding of neuromuscular blocking agents to mouse and human muscle nicotinic acetylcholine receptors",

abstract = "Nicotinic acetylcholine receptors (AChRs) are valuable therapeutic targets. To exploit them fully requires rapid assays for the evaluation of potentially therapeutic ligands and improved understanding of the interaction of such ligands with their receptor binding sites.",

keywords = "nicotinic, vecuronium, receptor, evolution, proline, phenylalanine, serine, binding",

author = "P. Gopal and R. Tate and E. Pow and D. Hill and J.G. Connolly",

year = "2007",

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AU - Gopal, P.

AU - Tate, R.

AU - Pow, E.

AU - Hill, D.

AU - Connolly, J.G.

PY - 2007

Y1 - 2007

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AB - Nicotinic acetylcholine receptors (AChRs) are valuable therapeutic targets. To exploit them fully requires rapid assays for the evaluation of potentially therapeutic ligands and improved understanding of the interaction of such ligands with their receptor binding sites.

KW - nicotinic

KW - vecuronium

KW - receptor

KW - evolution

KW - proline

KW - phenylalanine

KW - serine

KW - binding

UR - http://dx.doi.org/10.1038/sj.bjp.0707156

U2 - 10.1038/sj.bjp.0707156

DO - 10.1038/sj.bjp.0707156

M3 - Article

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VL - 150

SP - 920

EP - 931

JO - British Journal of Pharmacology

JF - British Journal of Pharmacology

IS - 7

ER -

The role of the amino acid residue at α1:189 in the binding of neuromuscular blocking agents to mouse and human muscle nicotinic acetylcholine receptors

Abstract

Keywords

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