The role of the amino acid residue at α1:189 in the binding of neuromuscular blocking agents to mouse and human muscle nicotinic acetylcholine receptors

P. Gopal, R. Tate, E. Pow, D. Hill, J.G. Connolly

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Nicotinic acetylcholine receptors (AChRs) are valuable therapeutic targets. To exploit them fully requires rapid assays for the evaluation of potentially therapeutic ligands and improved understanding of the interaction of such ligands with their receptor binding sites.
LanguageEnglish
Pages920-931
Number of pages11
JournalBritish Journal of Pharmacology
Volume150
Issue number7
DOIs
Publication statusPublished - 2007

Fingerprint

Neuromuscular Blocking Agents
Nicotinic Receptors
Ligands
Amino Acids
Muscles
Binding Sites
Therapeutics

Keywords

  • nicotinic
  • vecuronium
  • receptor
  • evolution
  • proline
  • phenylalanine
  • serine
  • binding

Cite this

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title = "The role of the amino acid residue at α1:189 in the binding of neuromuscular blocking agents to mouse and human muscle nicotinic acetylcholine receptors",
abstract = "Nicotinic acetylcholine receptors (AChRs) are valuable therapeutic targets. To exploit them fully requires rapid assays for the evaluation of potentially therapeutic ligands and improved understanding of the interaction of such ligands with their receptor binding sites.",
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author = "P. Gopal and R. Tate and E. Pow and D. Hill and J.G. Connolly",
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AU - Tate, R.

AU - Pow, E.

AU - Hill, D.

AU - Connolly, J.G.

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KW - vecuronium

KW - receptor

KW - evolution

KW - proline

KW - phenylalanine

KW - serine

KW - binding

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