Abstract
The enzymes that catalyze formation of the bioactive sphingolipid, sphingosine 1-phosphate, sphingosine kinase 1 and 2, are predictive markers in inflammatory diseases and cancer as evidenced by data from patients, knockout mice and the use of available molecular and chemical inhibitors. Thus, there is a compelling case for therapeutic targeting of sphingosine kinase. In addition, there are several examples of functional interaction between sphingosine 1-phosphate receptors and sphingosine kinase 1 that can drive malicious amplification loops that promote cancer cell growth. These novel aspects of sphingosine 1-phosphate pathobiology are reviewed herein.
| Language | English |
|---|---|
| Pages | 121-129 |
| Number of pages | 9 |
| Journal | Advances in Biological Regulation |
| Volume | 54 |
| Early online date | 11 Sep 2013 |
| DOIs | |
| Publication status | Published - Jan 2014 |
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Keywords
- sphingosine 1-phosphate
- cancer
- S1P
- cell growth
- inflammatory diseases
- sphingosine kinase
Cite this
}
The role of sphingosine 1-phosphate in inflammation and cancer. / Pyne, Nigel J; Ohotski, Jan; Bittman, Robert; Pyne, Susan.
In: Advances in Biological Regulation, Vol. 54, 01.2014, p. 121-129.Research output: Contribution to journal › Literature review
TY - JOUR
T1 - The role of sphingosine 1-phosphate in inflammation and cancer
AU - Pyne, Nigel J
AU - Ohotski, Jan
AU - Bittman, Robert
AU - Pyne, Susan
N1 - Notice: This is the author's version of a work that was accepted for publication in Advances in Biological Regulation. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in: Advances in Biological Regulation, The role of sphingosine 1-phosphate in inflammation and cancer, Pyne, N. J., Ohotski, J., Bittman, R. & Pyne, S. Jan 2014. 54, p. 121-129. DOI: 10.1016/j.jbior.2013.08.005.
PY - 2014/1
Y1 - 2014/1
N2 - The enzymes that catalyze formation of the bioactive sphingolipid, sphingosine 1-phosphate, sphingosine kinase 1 and 2, are predictive markers in inflammatory diseases and cancer as evidenced by data from patients, knockout mice and the use of available molecular and chemical inhibitors. Thus, there is a compelling case for therapeutic targeting of sphingosine kinase. In addition, there are several examples of functional interaction between sphingosine 1-phosphate receptors and sphingosine kinase 1 that can drive malicious amplification loops that promote cancer cell growth. These novel aspects of sphingosine 1-phosphate pathobiology are reviewed herein.
AB - The enzymes that catalyze formation of the bioactive sphingolipid, sphingosine 1-phosphate, sphingosine kinase 1 and 2, are predictive markers in inflammatory diseases and cancer as evidenced by data from patients, knockout mice and the use of available molecular and chemical inhibitors. Thus, there is a compelling case for therapeutic targeting of sphingosine kinase. In addition, there are several examples of functional interaction between sphingosine 1-phosphate receptors and sphingosine kinase 1 that can drive malicious amplification loops that promote cancer cell growth. These novel aspects of sphingosine 1-phosphate pathobiology are reviewed herein.
KW - sphingosine 1-phosphate
KW - cancer
KW - S1P
KW - cell growth
KW - inflammatory diseases
KW - sphingosine kinase
UR - http://www.journals.elsevier.com/advances-in-biological-regulation
U2 - 10.1016/j.jbior.2013.08.005
DO - 10.1016/j.jbior.2013.08.005
M3 - Literature review
VL - 54
SP - 121
EP - 129
JO - Advances in Biological Regulation
T2 - Advances in Biological Regulation
JF - Advances in Biological Regulation
SN - 2212-4934
ER -