The role of sphingosine 1-phosphate in inflammation and cancer

Nigel J Pyne, Jan Ohotski, Robert Bittman, Susan Pyne

Research output: Contribution to journalLiterature review

39 Citations (Scopus)
174 Downloads (Pure)

Abstract

The enzymes that catalyze formation of the bioactive sphingolipid, sphingosine 1-phosphate, sphingosine kinase 1 and 2, are predictive markers in inflammatory diseases and cancer as evidenced by data from patients, knockout mice and the use of available molecular and chemical inhibitors. Thus, there is a compelling case for therapeutic targeting of sphingosine kinase. In addition, there are several examples of functional interaction between sphingosine 1-phosphate receptors and sphingosine kinase 1 that can drive malicious amplification loops that promote cancer cell growth. These novel aspects of sphingosine 1-phosphate pathobiology are reviewed herein.

Original languageEnglish
Pages (from-to)121-129
Number of pages9
JournalAdvances in Biological Regulation
Volume54
Early online date11 Sep 2013
DOIs
Publication statusPublished - Jan 2014

Keywords

  • sphingosine 1-phosphate
  • cancer
  • S1P
  • cell growth
  • inflammatory diseases
  • sphingosine kinase

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