The role of sphingosine 1-phosphate in inflammation and cancer

Nigel J Pyne, Jan Ohotski, Robert Bittman, Susan Pyne

Research output: Contribution to journalLiterature review

36 Citations (Scopus)

Abstract

The enzymes that catalyze formation of the bioactive sphingolipid, sphingosine 1-phosphate, sphingosine kinase 1 and 2, are predictive markers in inflammatory diseases and cancer as evidenced by data from patients, knockout mice and the use of available molecular and chemical inhibitors. Thus, there is a compelling case for therapeutic targeting of sphingosine kinase. In addition, there are several examples of functional interaction between sphingosine 1-phosphate receptors and sphingosine kinase 1 that can drive malicious amplification loops that promote cancer cell growth. These novel aspects of sphingosine 1-phosphate pathobiology are reviewed herein.

LanguageEnglish
Pages121-129
Number of pages9
JournalAdvances in Biological Regulation
Volume54
Early online date11 Sep 2013
DOIs
Publication statusPublished - Jan 2014

Fingerprint

Inflammation
Neoplasms
Lysosphingolipid Receptors
Sphingolipids
Knockout Mice
sphingosine kinase
sphingosine 1-phosphate
Enzymes
Growth
Therapeutics

Keywords

  • sphingosine 1-phosphate
  • cancer
  • S1P
  • cell growth
  • inflammatory diseases
  • sphingosine kinase

Cite this

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abstract = "The enzymes that catalyze formation of the bioactive sphingolipid, sphingosine 1-phosphate, sphingosine kinase 1 and 2, are predictive markers in inflammatory diseases and cancer as evidenced by data from patients, knockout mice and the use of available molecular and chemical inhibitors. Thus, there is a compelling case for therapeutic targeting of sphingosine kinase. In addition, there are several examples of functional interaction between sphingosine 1-phosphate receptors and sphingosine kinase 1 that can drive malicious amplification loops that promote cancer cell growth. These novel aspects of sphingosine 1-phosphate pathobiology are reviewed herein.",
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The role of sphingosine 1-phosphate in inflammation and cancer. / Pyne, Nigel J; Ohotski, Jan; Bittman, Robert; Pyne, Susan.

In: Advances in Biological Regulation, Vol. 54, 01.2014, p. 121-129.

Research output: Contribution to journalLiterature review

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