The role of sphingosine 1-phosphate in inflammation and cancer

Nigel J Pyne; Jan Ohotski; Robert Bittman; Susan Pyne

doi:10.1016/j.jbior.2013.08.005

The role of sphingosine 1-phosphate in inflammation and cancer

Nigel J Pyne, Jan Ohotski, Robert Bittman, Susan Pyne

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Contribution to journal › Literature review › peer-review

43 Citations (Scopus)

192 Downloads (Pure)

Abstract

The enzymes that catalyze formation of the bioactive sphingolipid, sphingosine 1-phosphate, sphingosine kinase 1 and 2, are predictive markers in inflammatory diseases and cancer as evidenced by data from patients, knockout mice and the use of available molecular and chemical inhibitors. Thus, there is a compelling case for therapeutic targeting of sphingosine kinase. In addition, there are several examples of functional interaction between sphingosine 1-phosphate receptors and sphingosine kinase 1 that can drive malicious amplification loops that promote cancer cell growth. These novel aspects of sphingosine 1-phosphate pathobiology are reviewed herein.

Original language	English
Pages (from-to)	121-129
Number of pages	9
Journal	Advances in Biological Regulation
Volume	54
Early online date	11 Sep 2013
DOIs	https://doi.org/10.1016/j.jbior.2013.08.005
Publication status	Published - Jan 2014

Keywords

sphingosine 1-phosphate
cancer
S1P
cell growth
inflammatory diseases
sphingosine kinase

Access to Document

10.1016/j.jbior.2013.08.005

Pyne-etal-ABR2014-role-of-sphingosine-1-phosphate-in-inflammationAccepted author manuscript, 215 KB

http://www.journals.elsevier.com/advances-in-biological-regulation

Cite this

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title = "The role of sphingosine 1-phosphate in inflammation and cancer",

abstract = "The enzymes that catalyze formation of the bioactive sphingolipid, sphingosine 1-phosphate, sphingosine kinase 1 and 2, are predictive markers in inflammatory diseases and cancer as evidenced by data from patients, knockout mice and the use of available molecular and chemical inhibitors. Thus, there is a compelling case for therapeutic targeting of sphingosine kinase. In addition, there are several examples of functional interaction between sphingosine 1-phosphate receptors and sphingosine kinase 1 that can drive malicious amplification loops that promote cancer cell growth. These novel aspects of sphingosine 1-phosphate pathobiology are reviewed herein.",

keywords = "sphingosine 1-phosphate, cancer, S1P, cell growth, inflammatory diseases, sphingosine kinase",

author = "Pyne, {Nigel J} and Jan Ohotski and Robert Bittman and Susan Pyne",

note = "Notice: This is the author's version of a work that was accepted for publication in Advances in Biological Regulation. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in: Advances in Biological Regulation, The role of sphingosine 1-phosphate in inflammation and cancer, Pyne, N. J., Ohotski, J., Bittman, R. & Pyne, S. Jan 2014. 54, p. 121-129. DOI: 10.1016/j.jbior.2013.08.005.",

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language = "English",

volume = "54",

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AU - Pyne, Nigel J

AU - Ohotski, Jan

AU - Bittman, Robert

AU - Pyne, Susan

N1 - Notice: This is the author's version of a work that was accepted for publication in Advances in Biological Regulation. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in: Advances in Biological Regulation, The role of sphingosine 1-phosphate in inflammation and cancer, Pyne, N. J., Ohotski, J., Bittman, R. & Pyne, S. Jan 2014. 54, p. 121-129. DOI: 10.1016/j.jbior.2013.08.005.

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AB - The enzymes that catalyze formation of the bioactive sphingolipid, sphingosine 1-phosphate, sphingosine kinase 1 and 2, are predictive markers in inflammatory diseases and cancer as evidenced by data from patients, knockout mice and the use of available molecular and chemical inhibitors. Thus, there is a compelling case for therapeutic targeting of sphingosine kinase. In addition, there are several examples of functional interaction between sphingosine 1-phosphate receptors and sphingosine kinase 1 that can drive malicious amplification loops that promote cancer cell growth. These novel aspects of sphingosine 1-phosphate pathobiology are reviewed herein.

KW - sphingosine 1-phosphate

KW - cancer

KW - S1P

KW - cell growth

KW - inflammatory diseases

KW - sphingosine kinase

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