The role of residence time distribution in the continuous steady-state mixed suspension mixed product removal crystallization of glycine

Iyke I. Onyemelukwe, Anna R. Parsons, Helen P. Wheatcroft, Amy Robertson, Zoltan K. Nagy, Chris D. Rielly

Research output: Contribution to journalArticle

Abstract

In this work, a vacuum-driven intermittent transfer technique has been implemented to solve transfer line blockage issues and facilitate steady-state cooling crystallization studies of α-glycine in a single- and two-stage mixed suspension mixed product removal (MSMPR) crystallizer. Experimental residence time distribution (RTD) analysis of the stirred tank MSMPR cascade is performed using an imperfect pulse method of the axial dispersion model to benchmark the mixing performance against that of tubular crystallizers and determine the influence of RTD on steady-state size distribution of α-glycine product. Process analytical technology (PAT) is used to monitor and understand crystallization process dynamics, and the effect of MSMPR operating temperature, mean residence time, and number of MSMPR stages on mean particle size, crystal size distribution, and yield is studied. Results show the significance of nucleation and growth mechanisms alongside RTD in determining steady-state size distribution, and the need for optimum control of supersaturation to benefit from improved RTDs provided by multistage MSMPR crystallizers.

LanguageEnglish
Pages60-80
Number of pages21
JournalCrystal Growth and Design
Volume19
Issue number1
Early online date15 Nov 2018
DOIs
Publication statusPublished - 2 Jan 2019

Fingerprint

Residence time distribution
glycine
Crystallization
Glycine
Amino acids
Suspensions
Crystallizers
crystallization
products
Supersaturation
optimal control
supersaturation
operating temperature
Nucleation
Particle size
Vacuum
cascades
Cooling
Crystals
nucleation

Keywords

  • msmpr
  • continuous oscillatory baffled crystallizer
  • process analytical technology

Cite this

Onyemelukwe, Iyke I. ; Parsons, Anna R. ; Wheatcroft, Helen P. ; Robertson, Amy ; Nagy, Zoltan K. ; Rielly, Chris D. / The role of residence time distribution in the continuous steady-state mixed suspension mixed product removal crystallization of glycine. In: Crystal Growth and Design. 2019 ; Vol. 19, No. 1. pp. 60-80.
@article{add6d28cdd4c4b0495cb22ca9c2992ec,
title = "The role of residence time distribution in the continuous steady-state mixed suspension mixed product removal crystallization of glycine",
abstract = "In this work, a vacuum-driven intermittent transfer technique has been implemented to solve transfer line blockage issues and facilitate steady-state cooling crystallization studies of α-glycine in a single- and two-stage mixed suspension mixed product removal (MSMPR) crystallizer. Experimental residence time distribution (RTD) analysis of the stirred tank MSMPR cascade is performed using an imperfect pulse method of the axial dispersion model to benchmark the mixing performance against that of tubular crystallizers and determine the influence of RTD on steady-state size distribution of α-glycine product. Process analytical technology (PAT) is used to monitor and understand crystallization process dynamics, and the effect of MSMPR operating temperature, mean residence time, and number of MSMPR stages on mean particle size, crystal size distribution, and yield is studied. Results show the significance of nucleation and growth mechanisms alongside RTD in determining steady-state size distribution, and the need for optimum control of supersaturation to benefit from improved RTDs provided by multistage MSMPR crystallizers.",
keywords = "msmpr, continuous oscillatory baffled crystallizer, process analytical technology",
author = "Onyemelukwe, {Iyke I.} and Parsons, {Anna R.} and Wheatcroft, {Helen P.} and Amy Robertson and Nagy, {Zoltan K.} and Rielly, {Chris D.}",
year = "2019",
month = "1",
day = "2",
doi = "10.1021/acs.cgd.8b00853",
language = "English",
volume = "19",
pages = "60--80",
journal = "Crystal Growth and Design",
issn = "1528-7483",
publisher = "American Chemical Society",
number = "1",

}

The role of residence time distribution in the continuous steady-state mixed suspension mixed product removal crystallization of glycine. / Onyemelukwe, Iyke I.; Parsons, Anna R.; Wheatcroft, Helen P.; Robertson, Amy; Nagy, Zoltan K.; Rielly, Chris D.

In: Crystal Growth and Design, Vol. 19, No. 1, 02.01.2019, p. 60-80.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The role of residence time distribution in the continuous steady-state mixed suspension mixed product removal crystallization of glycine

AU - Onyemelukwe, Iyke I.

AU - Parsons, Anna R.

AU - Wheatcroft, Helen P.

AU - Robertson, Amy

AU - Nagy, Zoltan K.

AU - Rielly, Chris D.

PY - 2019/1/2

Y1 - 2019/1/2

N2 - In this work, a vacuum-driven intermittent transfer technique has been implemented to solve transfer line blockage issues and facilitate steady-state cooling crystallization studies of α-glycine in a single- and two-stage mixed suspension mixed product removal (MSMPR) crystallizer. Experimental residence time distribution (RTD) analysis of the stirred tank MSMPR cascade is performed using an imperfect pulse method of the axial dispersion model to benchmark the mixing performance against that of tubular crystallizers and determine the influence of RTD on steady-state size distribution of α-glycine product. Process analytical technology (PAT) is used to monitor and understand crystallization process dynamics, and the effect of MSMPR operating temperature, mean residence time, and number of MSMPR stages on mean particle size, crystal size distribution, and yield is studied. Results show the significance of nucleation and growth mechanisms alongside RTD in determining steady-state size distribution, and the need for optimum control of supersaturation to benefit from improved RTDs provided by multistage MSMPR crystallizers.

AB - In this work, a vacuum-driven intermittent transfer technique has been implemented to solve transfer line blockage issues and facilitate steady-state cooling crystallization studies of α-glycine in a single- and two-stage mixed suspension mixed product removal (MSMPR) crystallizer. Experimental residence time distribution (RTD) analysis of the stirred tank MSMPR cascade is performed using an imperfect pulse method of the axial dispersion model to benchmark the mixing performance against that of tubular crystallizers and determine the influence of RTD on steady-state size distribution of α-glycine product. Process analytical technology (PAT) is used to monitor and understand crystallization process dynamics, and the effect of MSMPR operating temperature, mean residence time, and number of MSMPR stages on mean particle size, crystal size distribution, and yield is studied. Results show the significance of nucleation and growth mechanisms alongside RTD in determining steady-state size distribution, and the need for optimum control of supersaturation to benefit from improved RTDs provided by multistage MSMPR crystallizers.

KW - msmpr

KW - continuous oscillatory baffled crystallizer

KW - process analytical technology

UR - http://www.scopus.com/inward/record.url?scp=85058137433&partnerID=8YFLogxK

UR - https://dspace.lboro.ac.uk/dspace-jspui/handle/2134/36061

U2 - 10.1021/acs.cgd.8b00853

DO - 10.1021/acs.cgd.8b00853

M3 - Article

VL - 19

SP - 60

EP - 80

JO - Crystal Growth and Design

T2 - Crystal Growth and Design

JF - Crystal Growth and Design

SN - 1528-7483

IS - 1

ER -