The role of lipid geometry in designing liposomes for the solubilisation of poorly water soluble drugs

M. Habib Ali, Behfar Moghaddam, Daniel J. Kirby, Afzal R. Mohammed, Yvonne Perrie

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Liposomes are well recognised for their ability to improve the delivery of a range of drugs. More commonly they are applied for the delivery of water-soluble drugs, but given their structural attributes, they can also be employed as solubilising agents for low solubility drugs as well as drug targeting agents. To further explore the potential of liposomes as solubilising agents, we have investigated the role of bilayer packaging in promoting drug solubilisation in liposome bilayers. The effect of alkyl chain length and symmetry was investigated to consider if using 'mis-matched' phospholipids could create 'voids' within the bilayers, and enhance bilayer loading capacity. Lipid packing was investigated using Langmuir studies, which demonstrated that increasing the alkyl chain length enhanced lipid packing, with condensed monolayers forming, whilst asymmetric lipids formed less condensed monolayers. However, this more open packing did not translate into improved drug loading, with the longer chain, condensed bilayers formed from long-chain, saturated lipids offering higher drug loading capacity. These studies demonstrate that liposomes formulated from longer chain, saturated lipids offer enhanced solubilisation capacity. However the molecular size, rather than lipophilicity, of the drug to be incorporated was also a key factor dominating bilayer incorporation efficiency.

LanguageEnglish
Pages225-32
Number of pages8
JournalInternational Journal of Pharmaceutics
Volume453
Issue number1
DOIs
Publication statusPublished - 30 Aug 2013

Fingerprint

Liposomes
Lipids
Water
Pharmaceutical Preparations
Product Packaging
Drug Delivery Systems
Solubility
Phospholipids

Keywords

  • chemistry, pharmaceutical
  • lipids
  • liposomes
  • Pharmaceutical Preparations
  • solubility
  • water

Cite this

Ali, M. Habib ; Moghaddam, Behfar ; Kirby, Daniel J. ; Mohammed, Afzal R. ; Perrie, Yvonne. / The role of lipid geometry in designing liposomes for the solubilisation of poorly water soluble drugs. In: International Journal of Pharmaceutics. 2013 ; Vol. 453, No. 1. pp. 225-32.
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The role of lipid geometry in designing liposomes for the solubilisation of poorly water soluble drugs. / Ali, M. Habib; Moghaddam, Behfar; Kirby, Daniel J.; Mohammed, Afzal R.; Perrie, Yvonne.

In: International Journal of Pharmaceutics, Vol. 453, No. 1, 30.08.2013, p. 225-32.

Research output: Contribution to journalArticle

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