Abstract

In recent years, the pharmaceutical industry is seeing a movement towards the implementation of more efficient continuous manufacturing. This shift requires the development of in-line process analytical technologies to monitor and control the process at any given time. However, extracting reliable information from these sensors is a challenge. Among the available technologies, in-line image analysis is quickly gaining importance. This work presents an image analysis framework developed to address one of the main challenges of in-line image analysis: the presence of out-of-focus particles. Through two relevant examples such as the characterisation of a system of microparticles of mixed shapes and the monitoring of a common operation in the pharmaceutical industry such as the wet milling process, the benefits of incorporating this technique are assessed. The realtime analysis of imaging data in combination with other simultaneously-acquired quantitative data streams enables the user to make informed decisions and implement enhanced control strategies.
Original languageEnglish
Title of host publicationAdvances in manufacturing technology XXXII
Subtitle of host publicationproceedings of the 16th International Conference on Manufacturing Research
EditorsPeter Thorvald, Keith Case
Place of PublicationNetherlands
PublisherIOS Press
Pages27-32
Number of pages6
ISBN (Print)978-1-61499-901-0
DOIs
Publication statusPublished - 11 Sep 2018
EventInternational Conference on Manufacturing Research - Skövde, Sweden
Duration: 11 Sep 201813 Sep 2018

Conference

ConferenceInternational Conference on Manufacturing Research
Abbreviated titleICMR '18
CountrySweden
City Skövde
Period11/09/1813/09/18

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Keywords

  • continuous manufacturing
  • digitisation
  • in-line imaging

Cite this

Cardona, J., Ferreira, C., Svoboda, V., Ahmed, B., McGinty, J., Agimelen, O. S., ... Tachtatzis, C. (2018). The role of in-line image analysis in the transition to continuous manufacturing in the pharmaceutical industry. In P. Thorvald, & K. Case (Eds.), Advances in manufacturing technology XXXII: proceedings of the 16th International Conference on Manufacturing Research (pp. 27-32). Netherlands: IOS Press. https://doi.org/10.3233/978-1-61499-902-7-27