The role of in-line image analysis in the transition to continuous manufacturing in the pharmaceutical industry

Javier Cardona; Carla Ferreira; Vaclav Svoboda; Bilal Ahmed; John McGinty; Okpeafoh S. Agimelen; Andrew Hamilton; Alison Cleary; Robert Atkinson; Craig Michie; Stephen Marshall; Alastair J. Florence; Yi-Chieh Chen; Jan Sefcik; Ivan Andonovic; Christos Tachtatzis

The role of in-line image analysis in the transition to continuous manufacturing in the pharmaceutical industry

Javier Cardona, Carla Ferreira, Vaclav Svoboda, Bilal Ahmed, John McGinty, Okpeafoh S. Agimelen, Andrew Hamilton, Alison Cleary, Robert Atkinson, Craig Michie, Stephen Marshall, Alastair J. Florence, Yi-Chieh Chen, Jan Sefcik, Ivan Andonovic, Christos Tachtatzis

Research output: Contribution to conference › Paper

Abstract

In recent years, the pharmaceutical industry is seeing a movement towards the implementation of more efficient continuous manufacturing. This shift requires the development of in-line process analytical technologies to monitor and control the process at any given time. However, extracting reliable information from these sensors is a challenge. Among the available technologies, in-line image analysis is quickly gaining importance. This work presents an image analysis framework developed to address one of the main challenges of in-line image analysis: the presence of out-of-focus particles. Through two relevant examples such as the characterisation of a system of microparticles of mixed shapes and the monitoring of a common operation in the pharmaceutical industry such as the wet milling process, the benefits of incorporating this technique are assessed. The realtime analysis of imaging data in combination with other simultaneously-acquired quantitative data streams enables the user to make informed decisions and implement enhanced control strategies.

Language	English
Number of pages	6
Publication status	Published - 11 Sep 2018
Event	International Conference on Manufacturing Research - Skövde, Sweden Duration: 11 Sep 2018 → 13 Sep 2018

Conference

Conference	International Conference on Manufacturing Research
Abbreviated title	ICMR '18
Country	Sweden
City	Skövde
Period	11/09/18 → 13/09/18

Fingerprint

Drug Industry

Drug products

Image analysis

Technology

Pharmaceutical Preparations

Industry

Imaging techniques

Monitoring

Sensors

Keywords

continuous manufacturing
digitisation
in-line imaging

Cite this

Cardona, J., Ferreira, C., Svoboda, V., Ahmed, B., McGinty, J., Agimelen, O. S., ... Tachtatzis, C. (2018). The role of in-line image analysis in the transition to continuous manufacturing in the pharmaceutical industry. Paper presented at International Conference on Manufacturing Research, Skövde, Sweden.

Cardona, Javier ; Ferreira, Carla ; Svoboda, Vaclav ; Ahmed, Bilal ; McGinty, John ; Agimelen, Okpeafoh S. ; Hamilton, Andrew ; Cleary, Alison ; Atkinson, Robert ; Michie, Craig ; Marshall, Stephen ; Florence, Alastair J. ; Chen, Yi-Chieh ; Sefcik, Jan ; Andonovic, Ivan ; Tachtatzis, Christos. / The role of in-line image analysis in the transition to continuous manufacturing in the pharmaceutical industry. Paper presented at International Conference on Manufacturing Research, Skövde, Sweden.6 p.

@conference{baba12ca0e334783b4a5fa851f4aebc8,

title = "The role of in-line image analysis in the transition to continuous manufacturing in the pharmaceutical industry",

abstract = "In recent years, the pharmaceutical industry is seeing a movement towards the implementation of more efficient continuous manufacturing. This shift requires the development of in-line process analytical technologies to monitor and control the process at any given time. However, extracting reliable information from these sensors is a challenge. Among the available technologies, in-line image analysis is quickly gaining importance. This work presents an image analysis framework developed to address one of the main challenges of in-line image analysis: the presence of out-of-focus particles. Through two relevant examples such as the characterisation of a system of microparticles of mixed shapes and the monitoring of a common operation in the pharmaceutical industry such as the wet milling process, the benefits of incorporating this technique are assessed. The realtime analysis of imaging data in combination with other simultaneously-acquired quantitative data streams enables the user to make informed decisions and implement enhanced control strategies.",

keywords = "continuous manufacturing, digitisation, in-line imaging",

author = "Javier Cardona and Carla Ferreira and Vaclav Svoboda and Bilal Ahmed and John McGinty and Agimelen, {Okpeafoh S.} and Andrew Hamilton and Alison Cleary and Robert Atkinson and Craig Michie and Stephen Marshall and Florence, {Alastair J.} and Yi-Chieh Chen and Jan Sefcik and Ivan Andonovic and Christos Tachtatzis",

year = "2018",

month = "9",

day = "11",

language = "English",

note = "International Conference on Manufacturing Research, ICMR '18 ; Conference date: 11-09-2018 Through 13-09-2018",

}

Cardona, J , Ferreira, C , Svoboda, V , Ahmed, B , McGinty, J, Agimelen, OS, Hamilton, A , Cleary, A , Atkinson, R , Michie, C , Marshall, S , Florence, AJ , Chen, Y-C , Sefcik, J , Andonovic, I & Tachtatzis, C 2018, 'The role of in-line image analysis in the transition to continuous manufacturing in the pharmaceutical industry' Paper presented at International Conference on Manufacturing Research, Skövde, Sweden, 11/09/18 - 13/09/18, .

The role of in-line image analysis in the transition to continuous manufacturing in the pharmaceutical industry. / Cardona, Javier ; Ferreira, Carla ; Svoboda, Vaclav ; Ahmed, Bilal ; McGinty, John; Agimelen, Okpeafoh S.; Hamilton, Andrew ; Cleary, Alison ; Atkinson, Robert ; Michie, Craig ; Marshall, Stephen ; Florence, Alastair J.; Chen, Yi-Chieh ; Sefcik, Jan ; Andonovic, Ivan ; Tachtatzis, Christos.

2018. Paper presented at International Conference on Manufacturing Research, Skövde, Sweden.

Research output: Contribution to conference › Paper

TY - CONF

T1 - The role of in-line image analysis in the transition to continuous manufacturing in the pharmaceutical industry

AU - Cardona, Javier

AU - Ferreira, Carla

AU - Svoboda, Vaclav

AU - Ahmed, Bilal

AU - McGinty, John

AU - Agimelen, Okpeafoh S.

AU - Hamilton, Andrew

AU - Cleary, Alison

AU - Atkinson, Robert

AU - Michie, Craig

AU - Marshall, Stephen

AU - Florence, Alastair J.

AU - Chen, Yi-Chieh

AU - Sefcik, Jan

AU - Andonovic, Ivan

AU - Tachtatzis, Christos

PY - 2018/9/11

Y1 - 2018/9/11

N2 - In recent years, the pharmaceutical industry is seeing a movement towards the implementation of more efficient continuous manufacturing. This shift requires the development of in-line process analytical technologies to monitor and control the process at any given time. However, extracting reliable information from these sensors is a challenge. Among the available technologies, in-line image analysis is quickly gaining importance. This work presents an image analysis framework developed to address one of the main challenges of in-line image analysis: the presence of out-of-focus particles. Through two relevant examples such as the characterisation of a system of microparticles of mixed shapes and the monitoring of a common operation in the pharmaceutical industry such as the wet milling process, the benefits of incorporating this technique are assessed. The realtime analysis of imaging data in combination with other simultaneously-acquired quantitative data streams enables the user to make informed decisions and implement enhanced control strategies.

AB - In recent years, the pharmaceutical industry is seeing a movement towards the implementation of more efficient continuous manufacturing. This shift requires the development of in-line process analytical technologies to monitor and control the process at any given time. However, extracting reliable information from these sensors is a challenge. Among the available technologies, in-line image analysis is quickly gaining importance. This work presents an image analysis framework developed to address one of the main challenges of in-line image analysis: the presence of out-of-focus particles. Through two relevant examples such as the characterisation of a system of microparticles of mixed shapes and the monitoring of a common operation in the pharmaceutical industry such as the wet milling process, the benefits of incorporating this technique are assessed. The realtime analysis of imaging data in combination with other simultaneously-acquired quantitative data streams enables the user to make informed decisions and implement enhanced control strategies.

KW - continuous manufacturing

KW - digitisation

KW - in-line imaging

UR - http://www.icmr.org.uk/

M3 - Paper

ER -

Cardona J , Ferreira C , Svoboda V , Ahmed B , McGinty J, Agimelen OS et al. The role of in-line image analysis in the transition to continuous manufacturing in the pharmaceutical industry. 2018. Paper presented at International Conference on Manufacturing Research, Skövde, Sweden.