The role of IL-4R alpha signalling during toxoplasma gondii infection

T. Mokgethi, M.B. Nickdel, F.L. Henriquez, F. Roberts, F. Brombacher, Craig Roberts, J. Alexander

Research output: Contribution to journalArticle

Abstract

The protective immune response against Toxoplasma gondii is widely recognised as being type-1 mediated. Nevertheless, the overproduction of type-1 cytokines can induce severe pathology. The extent to which Th2 cytokines can modulate the disease protective versus disease exacerbating effects of type-1 cytokines remains to be resolved. We have therefore, compared the disease induced by T. gondii cysts in IL-4)/), IL-4Ra)/), and wild-type BALB/c mice, a mouse strain normally resistant to this disease. Increased mortality and increased lung pathology were observed in the absence of IL-4 and signalling via IL-4Ra and splenocyte type 1 cytokine and NO production was increased during early infection (day 12). IL-4 can modulate type-1 inflammatory responses by counter-regulating the effects of IFN-c on CD4+ T cells and/or macrophages.
LanguageEnglish
Article numberOP 105
Pages110-110
Number of pages1
JournalImmunology
Volume125
Issue numbers1
DOIs
Publication statusPublished - Dec 2008

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Toxoplasmosis
Interleukin-4
Cytokines
Toxoplasma
Cysts
Macrophages
Pathology
T-Lymphocytes
Mortality
Infection

Keywords

  • IL-4R alpha signalling
  • toxoplasma gondii infection

Cite this

Mokgethi, T. ; Nickdel, M.B. ; Henriquez, F.L. ; Roberts, F. ; Brombacher, F. ; Roberts, Craig ; Alexander, J. / The role of IL-4R alpha signalling during toxoplasma gondii infection. In: Immunology. 2008 ; Vol. 125, No. s1. pp. 110-110.
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The role of IL-4R alpha signalling during toxoplasma gondii infection. / Mokgethi, T.; Nickdel, M.B.; Henriquez, F.L.; Roberts, F.; Brombacher, F.; Roberts, Craig; Alexander, J.

In: Immunology, Vol. 125, No. s1, OP 105, 12.2008, p. 110-110.

Research output: Contribution to journalArticle

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AU - Mokgethi, T.

AU - Nickdel, M.B.

AU - Henriquez, F.L.

AU - Roberts, F.

AU - Brombacher, F.

AU - Roberts, Craig

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