The role of IL-4R alpha signalling during toxoplasma gondii infection

T. Mokgethi, M.B. Nickdel, F.L. Henriquez, F. Roberts, F. Brombacher, Craig Roberts, J. Alexander

Research output: Contribution to journalArticle

Abstract

The protective immune response against Toxoplasma gondii is widely recognised as being type-1 mediated. Nevertheless, the overproduction of type-1 cytokines can induce severe pathology. The extent to which Th2 cytokines can modulate the disease protective versus disease exacerbating effects of type-1 cytokines remains to be resolved. We have therefore, compared the disease induced by T. gondii cysts in IL-4)/), IL-4Ra)/), and wild-type BALB/c mice, a mouse strain normally resistant to this disease. Increased mortality and increased lung pathology were observed in the absence of IL-4 and signalling via IL-4Ra and splenocyte type 1 cytokine and NO production was increased during early infection (day 12). IL-4 can modulate type-1 inflammatory responses by counter-regulating the effects of IFN-c on CD4+ T cells and/or macrophages.
Original languageEnglish
Article numberOP 105
Pages (from-to)110-110
Number of pages1
JournalImmunology
Volume125
Issue numbers1
DOIs
Publication statusPublished - Dec 2008

Keywords

  • IL-4R alpha signalling
  • toxoplasma gondii infection

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