The role of G-protein coupled receptors and associated proteins in receptor tyrosine kinase signal transduction

Catherine Waters, Susan Pyne, Nigel J Pyne

Research output: Contribution to journalLiterature review

73 Citations (Scopus)

Abstract

It is well established that stimulation of G-protein coupled receptors (GPCRs) can activate signalling from receptor tyrosine kinases by a process termed transactivation. Indeed, in recent years, it has become apparent that transactivation is a general phenomenon that has been demonstrated for many unrelated GPCRs and receptor tyrosine kinases. In this case the GPCR/G-protein participation is up-stream of the receptor tyrosine kinase. Substantial research has addressed these findings but meanwhile another mechanism of cross talk has been slowly emerging. For over a decade, a growing body of evidence has demonstrated that numerous growth factors use G-proteins and attendant signalling molecules such as beta-arrestins that participate down-stream of the receptor tyrosine kinase to signal to effectors, such as p42/p44 MAPK. This review highlights this novel mechanism of cross talk between receptor tyrosine kinases and GPCRs, which is distinct from growth factor receptor transactivation by GPCRs.
LanguageEnglish
Pages309-323
Number of pages15
JournalSeminars in Cell and Developmental Biology
Volume15
Issue number3
DOIs
Publication statusPublished - Jun 2004

Fingerprint

Receptor Protein-Tyrosine Kinases
G-Protein-Coupled Receptors
Signal Transduction
Transcriptional Activation
GTP-Binding Proteins
Receptor Cross-Talk
Mitogen-Activated Protein Kinase 3
Growth Factor Receptors
Mitogen-Activated Protein Kinase 1
Intercellular Signaling Peptides and Proteins
Research

Keywords

  • humans
  • phosphorylation
  • receptor protein-tyrosine Kinases
  • receptors, G-protein-coupled
  • signal transduction
  • transcriptional activation

Cite this

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The role of G-protein coupled receptors and associated proteins in receptor tyrosine kinase signal transduction. / Waters, Catherine; Pyne, Susan; Pyne, Nigel J.

In: Seminars in Cell and Developmental Biology , Vol. 15, No. 3, 06.2004, p. 309-323.

Research output: Contribution to journalLiterature review

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AU - Waters, Catherine

AU - Pyne, Susan

AU - Pyne, Nigel J

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AB - It is well established that stimulation of G-protein coupled receptors (GPCRs) can activate signalling from receptor tyrosine kinases by a process termed transactivation. Indeed, in recent years, it has become apparent that transactivation is a general phenomenon that has been demonstrated for many unrelated GPCRs and receptor tyrosine kinases. In this case the GPCR/G-protein participation is up-stream of the receptor tyrosine kinase. Substantial research has addressed these findings but meanwhile another mechanism of cross talk has been slowly emerging. For over a decade, a growing body of evidence has demonstrated that numerous growth factors use G-proteins and attendant signalling molecules such as beta-arrestins that participate down-stream of the receptor tyrosine kinase to signal to effectors, such as p42/p44 MAPK. This review highlights this novel mechanism of cross talk between receptor tyrosine kinases and GPCRs, which is distinct from growth factor receptor transactivation by GPCRs.

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