The role of antibodies in the treatment of SARS-CoV-2 virus infection, and evaluating their contribution to antibody-dependent enhancement of infection

Mohammed A. H. Farouq; Reinaldo Acevedo; Valerie A. Ferro; Paul A. Mulheran; Mohammed M. Al Qaraghuli

doi:10.3390/ijms23116078

The role of antibodies in the treatment of SARS-CoV-2 virus infection, and evaluating their contribution to antibody-dependent enhancement of infection

Mohammed A. H. Farouq, Reinaldo Acevedo, Valerie A. Ferro, Paul A. Mulheran, Mohammed M. Al Qaraghuli

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

34 Downloads (Pure)

Abstract

Antibodies play a crucial role in the immune response, in fighting off pathogens as well as helping create strong immunological memory. Antibody-dependent enhancement (ADE) occurs when non-neutralising antibodies recognise and bind to a pathogen, but are unable to prevent infection, and is widely known and is reported as occurring in infection caused by several viruses. This narrative review explores the ADE phenomenon, its occurrence in viral infections and evaluates its role in infection by SARS-CoV-2 virus, which causes coronavirus disease 2019 (COVID-19). As of yet, there is no clear evidence of ADE in SARS-CoV-2, though this area is still subject to further study.

Original language	English
Article number	6078
Number of pages	18
Journal	International Journal of Molecular Sciences
Volume	23
Issue number	11
DOIs	https://doi.org/10.3390/ijms23116078
Publication status	Published - 28 May 2022

Funding

Funding: M.A.H.F is funded by BBSRC UK grant number BB/T508792/1. M.M.A.Q acknowledges financial support from the EPSRC grant No. EP/R51178X/1.

Keywords

coronavirus
SARS-CoV-2
antibody-dependent enhancement
COVID-19

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.3390/ijms23116078Licence: CC BY 4.0

Farouq-etal-IJMS-2022-The-role-of-antibodies-in-the-treatment-of-SARS-CoV-2-virus-infectionFinal published version, 1.32 MBLicence: CC BY 4.0

Therapeutic Design for Nasal Powder Delivery (IBioIC CTP)
Mulheran, P. (Principal Investigator) & Ferro, V. (Co-investigator)
BBSRC (Biotech & Biological Sciences Research Council)
1/02/20 → 31/01/24
Project: Research - Studentship Case
Optimal conjugation routes for antibody-based point-of-care testing kits
Mulheran, P. (Principal Investigator) & Ferro, V. (Academic)
EPSRC (Engineering and Physical Sciences Research Council)
1/04/17 → 31/03/21
Project: Research - Internally Allocated

Cite this

@article{22c49f8acc8f4765a019892ae2f661be,

title = "The role of antibodies in the treatment of SARS-CoV-2 virus infection, and evaluating their contribution to antibody-dependent enhancement of infection",

abstract = "Antibodies play a crucial role in the immune response, in fighting off pathogens as well as helping create strong immunological memory. Antibody-dependent enhancement (ADE) occurs when non-neutralising antibodies recognise and bind to a pathogen, but are unable to prevent infection, and is widely known and is reported as occurring in infection caused by several viruses. This narrative review explores the ADE phenomenon, its occurrence in viral infections and evaluates its role in infection by SARS-CoV-2 virus, which causes coronavirus disease 2019 (COVID-19). As of yet, there is no clear evidence of ADE in SARS-CoV-2, though this area is still subject to further study.",

keywords = "coronavirus, SARS-CoV-2, antibody-dependent enhancement, COVID-19",

author = "Farouq, {Mohammed A. H.} and Reinaldo Acevedo and Ferro, {Valerie A.} and Mulheran, {Paul A.} and {Al Qaraghuli}, {Mohammed M.}",

year = "2022",

month = may,

day = "28",

doi = "10.3390/ijms23116078",

language = "English",

volume = "23",

journal = "International Journal of Molecular Sciences",

issn = "1422-0067",

publisher = "MDPI AG",

number = "11",

}

The role of antibodies in the treatment of SARS-CoV-2 virus infection, and evaluating their contribution to antibody-dependent enhancement of infection. / Farouq, Mohammed A. H.; Acevedo, Reinaldo; Ferro, Valerie A. et al.
In: International Journal of Molecular Sciences, Vol. 23, No. 11, 6078, 28.05.2022.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - The role of antibodies in the treatment of SARS-CoV-2 virus infection, and evaluating their contribution to antibody-dependent enhancement of infection

AU - Farouq, Mohammed A. H.

AU - Acevedo, Reinaldo

AU - Ferro, Valerie A.

AU - Mulheran, Paul A.

AU - Al Qaraghuli, Mohammed M.

PY - 2022/5/28

Y1 - 2022/5/28

N2 - Antibodies play a crucial role in the immune response, in fighting off pathogens as well as helping create strong immunological memory. Antibody-dependent enhancement (ADE) occurs when non-neutralising antibodies recognise and bind to a pathogen, but are unable to prevent infection, and is widely known and is reported as occurring in infection caused by several viruses. This narrative review explores the ADE phenomenon, its occurrence in viral infections and evaluates its role in infection by SARS-CoV-2 virus, which causes coronavirus disease 2019 (COVID-19). As of yet, there is no clear evidence of ADE in SARS-CoV-2, though this area is still subject to further study.

AB - Antibodies play a crucial role in the immune response, in fighting off pathogens as well as helping create strong immunological memory. Antibody-dependent enhancement (ADE) occurs when non-neutralising antibodies recognise and bind to a pathogen, but are unable to prevent infection, and is widely known and is reported as occurring in infection caused by several viruses. This narrative review explores the ADE phenomenon, its occurrence in viral infections and evaluates its role in infection by SARS-CoV-2 virus, which causes coronavirus disease 2019 (COVID-19). As of yet, there is no clear evidence of ADE in SARS-CoV-2, though this area is still subject to further study.

KW - coronavirus

KW - SARS-CoV-2

KW - antibody-dependent enhancement

KW - COVID-19

U2 - 10.3390/ijms23116078

DO - 10.3390/ijms23116078

M3 - Article

SN - 1422-0067

VL - 23

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

IS - 11

M1 - 6078

ER -

The role of antibodies in the treatment of SARS-CoV-2 virus infection, and evaluating their contribution to antibody-dependent enhancement of infection

Abstract

Funding

Keywords

UN SDGs

Access to Document

Fingerprint

Projects

Therapeutic Design for Nasal Powder Delivery (IBioIC CTP)

Optimal conjugation routes for antibody-based point-of-care testing kits

Cite this