The role of androgen receptors in atherosclerosis

Kaloyan Takov, Junxi Wu, Martin A. Denvir, Lee B. Smith, Patrick W.F. Hadoke

Research output: Contribution to journalReview articlepeer-review

12 Citations (Scopus)

Abstract

Male disadvantage in cardiovascular health is well recognised. However, the influence of androgens on atherosclerosis, one of the major causes of many life-threatening cardiovascular events, is not well understood. With the dramatic increase in clinical prescription of testosterone in the past decade, concerns about the cardiovascular side-effects of androgen supplementation or androgen deprivation therapy are increasing. Potential atheroprotective effects of testosterone could be secondary to (aromatase-mediated) conversion into oestradiol or, alternatively, to direct activation of androgen receptors (AR). Recent development of animal models with cell-specific AR knockout has indicated a complex role for androgen action in atherosclerosis. Most studies suggest androgens are atheroprotective but the precise role of AR remains unclear. Increased use of AR knockout models should clarify the role of AR in atherogenesis and, thus, lead to exploitation of this pathway as a therapeutic target.

Original languageEnglish
Pages (from-to)82-91
Number of pages10
JournalMolecular and Cellular Endocrinology
Volume465
Early online date9 Oct 2017
DOIs
Publication statusPublished - 15 Apr 2018

Keywords

  • androgen receptor
  • atherosclerosis
  • cardiovascular disease
  • testosterone

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