The regulation of abscission by multi-protein complexes

Hélia Neto, Gwyn W. Gould

Research output: Contribution to journalComment/debate

31 Citations (Scopus)

Abstract

The terminal stage of cytokinesis - a process termed abscission - is the severing of the thin intercellular bridge that connects the two daughter cells. Recent work provides new insight into the mechanism by which this microtubule-dense membrane bridge is resolved, and highlights important roles for multi-protein assemblies in different facets of abscission. These include the endosomal sorting complex required for transport (ESCRT), which appears to have a decisive role in the final scission event, and vesicle tethering complexes, which potentially act at an earlier stage, and might serve to prepare the abscission site. Here, we review recent studies of the structure, function and regulation of these complexes as related to abscission. We focus largely on studies of cytokinesis in mammalian cells. However, cell division in other systems, such as plants and Archae, is also considered, reflecting the mechanistic conservation of membrane-scission processes during cell division.

LanguageEnglish
Pages3199-3207
Number of pages9
JournalJournal of Cell Science
Volume124
Issue number19
DOIs
Publication statusPublished - 1 Oct 2011

Fingerprint

Cytokinesis
Cell Division
Endosomal Sorting Complexes Required for Transport
Membranes
Microtubules
Proteins

Keywords

  • abscission
  • ESCRT complex
  • exocyst complex
  • membrane trafficking

Cite this

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The regulation of abscission by multi-protein complexes. / Neto, Hélia; Gould, Gwyn W.

In: Journal of Cell Science, Vol. 124, No. 19, 01.10.2011, p. 3199-3207.

Research output: Contribution to journalComment/debate

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AU - Gould, Gwyn W.

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