The re-emergence of natural products for drug discovery in the genomics era

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1014 Citations (Scopus)
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Abstract

Natural products have been a rich source of compounds for drug discovery. However, their use has diminished in the past two decades, in part because of technical barriers to screening natural products in high-throughput assays against molecular targets. Here, we review strategies for natural product screening that harness the recent technical advances that have reduced these barriers. We also assess the use of genomic and metabolomic approaches to augment traditional methods of studying natural products, and highlight recent examples of natural products in antimicrobial drug discovery and as inhibitors of protein-protein interactions. The growing appreciation of functional assays and phenotypic screens may further contribute to a revival of interest in natural products for drug discovery.
Original languageEnglish
Pages (from-to)111–129
Number of pages19
JournalNature Reviews Drug Discovery
Volume14
DOIs
Publication statusPublished - 23 Jan 2015

Keywords

  • drug discovery
  • genomics
  • natural products
  • molecular targets

Research Output

  • 1014 Citations
  • 6 Article

Metabolomics-guided isolation of anti-trypanosomal metabolites from the endophytic fungus Lasiodiplodia theobromae

Kamal, N., Viegelmann, C. V., Clements, C. J. & Edrada-Ebel, R., 19 Oct 2016, In : Planta Medica.

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    Using molecular networking for microbial secondary metabolite bioprospecting

    Purves, K., Macintyre, L., Brennan, D., Hreggviðsson, G. Ó., Kuttner, E., Ásgeirsdóttir, M. E., Young, L. C., Green, D. H., Edrada-Ebel, R. & Duncan, K., 8 Jan 2016, In : Metabolites. 6, 1, 18 p., 2.

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  • 21 Citations (Scopus)
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    Biodiversity, anti-trypanosomal activity screening, and metabolomic profiling of actinomycetes isolated from Mediterranean sponges

    Cheng, C., Macintyre, L., Abdelmohsen, U. R., Horn, H., Polymenakou, P. N., Edrada-Ebel, R. & Hentschel, U., 25 Sep 2015, In : PLOS One. 10, 9, 21 p., e0138528.

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  • 35 Citations (Scopus)
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