The rational design of vaccines

Vincent W. Bramwell, Yvonne Perrie

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

This review provides an insight into the various opportunities for vaccine intervention, analysis of strategies for vaccine development, vaccine ability to modulate immune responses and resultant rational vaccine design. In addition, wider aspects are considered, such as biotechnological advances, advances in immunological understanding and host-pathogen interactions. The key question addressed here is, with all our research and understanding, have we reached a new echelon in vaccine development, that of rational design?

LanguageEnglish
Pages1527-1534
Number of pages8
JournalDrug Discovery Today
Volume10
Issue number22
DOIs
Publication statusPublished - 15 Nov 2005

Fingerprint

Vaccines
Host-Pathogen Interactions
Research

Keywords

  • vaccine design
  • rational design
  • vaccines
  • delivery systems
  • adjuvants
  • biotechnology

Cite this

Bramwell, Vincent W. ; Perrie, Yvonne. / The rational design of vaccines. In: Drug Discovery Today. 2005 ; Vol. 10, No. 22. pp. 1527-1534.
@article{67b6050cfc784c288918efd5ed1cbd8b,
title = "The rational design of vaccines",
abstract = "This review provides an insight into the various opportunities for vaccine intervention, analysis of strategies for vaccine development, vaccine ability to modulate immune responses and resultant rational vaccine design. In addition, wider aspects are considered, such as biotechnological advances, advances in immunological understanding and host-pathogen interactions. The key question addressed here is, with all our research and understanding, have we reached a new echelon in vaccine development, that of rational design?",
keywords = "vaccine design, rational design, vaccines, delivery systems, adjuvants, biotechnology",
author = "Bramwell, {Vincent W.} and Yvonne Perrie",
year = "2005",
month = "11",
day = "15",
doi = "10.1016/S1359-6446(05)03600-7",
language = "English",
volume = "10",
pages = "1527--1534",
journal = "Drug Discovery Today",
issn = "1359-6446",
number = "22",

}

The rational design of vaccines. / Bramwell, Vincent W.; Perrie, Yvonne.

In: Drug Discovery Today, Vol. 10, No. 22, 15.11.2005, p. 1527-1534.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The rational design of vaccines

AU - Bramwell, Vincent W.

AU - Perrie, Yvonne

PY - 2005/11/15

Y1 - 2005/11/15

N2 - This review provides an insight into the various opportunities for vaccine intervention, analysis of strategies for vaccine development, vaccine ability to modulate immune responses and resultant rational vaccine design. In addition, wider aspects are considered, such as biotechnological advances, advances in immunological understanding and host-pathogen interactions. The key question addressed here is, with all our research and understanding, have we reached a new echelon in vaccine development, that of rational design?

AB - This review provides an insight into the various opportunities for vaccine intervention, analysis of strategies for vaccine development, vaccine ability to modulate immune responses and resultant rational vaccine design. In addition, wider aspects are considered, such as biotechnological advances, advances in immunological understanding and host-pathogen interactions. The key question addressed here is, with all our research and understanding, have we reached a new echelon in vaccine development, that of rational design?

KW - vaccine design

KW - rational design

KW - vaccines

KW - delivery systems

KW - adjuvants

KW - biotechnology

U2 - 10.1016/S1359-6446(05)03600-7

DO - 10.1016/S1359-6446(05)03600-7

M3 - Article

VL - 10

SP - 1527

EP - 1534

JO - Drug Discovery Today

T2 - Drug Discovery Today

JF - Drug Discovery Today

SN - 1359-6446

IS - 22

ER -