The rational design of vaccines

Vincent W. Bramwell, Yvonne Perrie

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

This review provides an insight into the various opportunities for vaccine intervention, analysis of strategies for vaccine development, vaccine ability to modulate immune responses and resultant rational vaccine design. In addition, wider aspects are considered, such as biotechnological advances, advances in immunological understanding and host-pathogen interactions. The key question addressed here is, with all our research and understanding, have we reached a new echelon in vaccine development, that of rational design?

Original languageEnglish
Pages (from-to)1527-1534
Number of pages8
JournalDrug Discovery Today
Volume10
Issue number22
DOIs
Publication statusPublished - 15 Nov 2005

Keywords

  • vaccine design
  • rational design
  • vaccines
  • delivery systems
  • adjuvants
  • biotechnology

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